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Development of a coated vascular prosthesis cope with BSE problems

开发涂层人造血管应对疯牛病问题

基本信息

批准号：
17390384
负责人：
NOISHIKI Yasuharu
金额：
$ 10.21万
依托单位：
Yokohama City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17390384/
关键词：
Blood vessel prostheses Bovine Sponeious Encepharopathy Biomaterials collagen Ultra-fine polyester fiber chitin chitosan

项目摘要

In order to cope with bovine spongious encepharopathy problems, a fabric vascular prosthesis coated with biodegradable materials was developed. All the blood vessel prostheses commercially available are coated with bovine collagen. Our project was aimed to obtain coating materials free from bovine spongious encepharopathy, and suitable basic materials for the coating as a vascular prostheses. Among various biodegradable materials, we selected non-pathological protein free substances, such as cellulose, extremely high molecule hyaluronic acid, polyethylene glycol, polyvinyl alcohol, chitin, chitosan, and their substrates. After examinations, our experiments showed that the most suitable materials for this purpose were chitin, chitosan, and carboxymethyl cellulose(CMC). Our efforts were also on how to fix these materials on fabric prostheses. We checked chemical reagents such as formaldehyde, glutarardehyde and carbodiimide. All of them showed toxicity. From these results, we adopted physical methods such as gamma-ray irradiation, ultraviolet irradiation, electron beam irradiation, heat cross-linking, entanglement of each material fiber. Finally, we chose entanglement method. This was a simple method, but it did not show any toxic reactions. Next target of our experiment was to create a best matrix of the fabric vascular prosthesis for the coating. For this purpose, we developed a prosthesis fabricated with ultra-fine polyester fibers. They can trap the coated substance very firmly. With these basic experiments, fabric prostheses made of ultrafine polyester fibers coated with CMC, Chitin, and chitosan. We implanted the created prostheses into the thoracic descending aortae of dogs. The graft showed expected results. We are now underway to observe these vascular grafts with in vivo experiment for long-term analysis.

为了解决牛海绵状脑病的问题，研制了一种生物可降解材料涂层的织物血管假体。市面上所有的血管假体都涂有牛胶原蛋白。本项目旨在获得不含牛海绵状脑病的涂层材料，以及适合作为血管假体的涂层基础材料。在各种生物降解材料中，我们选择了非病理性无蛋白物质，如纤维素、超高分子透明质酸、聚乙二醇、聚乙烯醇、几丁质、壳聚糖及其底物。实验结果表明，甲壳素、壳聚糖和羧甲基纤维素（CMC）是最合适的材料。我们也在研究如何将这些材料固定在织物假肢上。我们检查了甲醛、戊二醛和碳二亚胺等化学试剂。它们都显示出毒性。根据这些结果，我们采用了伽马射线辐照、紫外辐照、电子束辐照、热交联、缠结等物理方法对每一种材料纤维进行了研究。最后，我们选择了纠缠法。这是一种简单的方法，但没有显示出任何毒性反应。我们实验的下一个目标是为涂层创造一个最佳的织物血管假体基质。为此，我们开发了一种由超细聚酯纤维制成的假体。它们可以非常牢固地捕获被涂层的物质。通过这些基础实验，将超细聚酯纤维涂覆CMC、几丁质和壳聚糖制成织物假体。我们将自制的假体植入狗的胸降主动脉。移植显示出预期的效果。目前，我们正在对这些血管移植进行体内观察和长期分析。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

心筋組織内の任意の場所に任意の形態の血管を創る

在心肌组织内的任何位置创建任何形状的血管

DOI：
发表时间：
2008
期刊：
The Japanese Association for Thoracic Surgery 55(2)
影响因子：
0
作者：
Misaki N;Yamamoto Y;Okamoto T;Chang SS;Igai H;Gotoh M;Tabata Y;Yokomise H.;野一色泰晴
通讯作者：
野一色泰晴

人工臓器における材料の問題点(有機・無機・金属)

人造器官材料的问题（有机、无机、金属）