Fundamental research for the development of a growable vascular graft

一种可以随着受体生长而生长的血管移植物被开发出来。植入小狗的胸降主动脉的移植物在植入后一年内缓慢生长到预期的大小。以人大隐静脉为基质材料。它被浸泡在蒸馏水中并超声处理，导致细胞破坏，然后与聚环氧化合物进行交联，以获得受控的生物降解性、亲水性和抗血栓形成性能。将4根内径为10 mm的聚脂网状管包裹的4根内径移植物植入11只幼犬体内。移植物直径由原来的4 mm增加到9.5 mm。1年后，用聚酯网加固的移植物壁上覆盖有内皮细胞。可生长移植物的要求如下：1)小口径移植物的抗血栓形成能力；2)生长和终止生长的能力。大于接枝物的聚酯网管在预期直径处导致生长停滞，而生长速度受接枝交联度的控制。用这种方法，可以通过改变原始移植物及其周围的聚酯网管的大小来制作任何尺寸的移植物。

A vascualr graft that can grow with the growth of its recipient was developed. The graft implanted in the thoracic descending aorta grew slowly to the expected size within a year after implantation in puppies. Human saphenous vein was used as the substrate material. It was dipped into distilled water and sonicated, resulting in cell destruction, and followed by cross-linking with a polyepoxy compound to give both controlled biodegradability, hydrophilicity, and antithrombogenic properties. Four milimeter inner diameter (ID) grafts, enveloped with polyester mesh tubes of 10 mm ID, were implanted in 11 puppies. The diameter of the grafts grew to 9.5 mm from their original 4 mm. After 1 year, the graft wall that were reinforced with polyester mesh were coveredlwith endothelial cells. The following requirements were provided in a growable graft: 1) anthithrombogenicity in a small caliber graft; 2) ability to grow as well as to terminate growth. The polyester mesh tube, which was larger than the graft, caused arrest of growth at the expected diameter, whereas the growth rate was controlled by the degree of graft cross-linking. With this method, any size graft can be made by changing the size of the original graft and the polyester mesh tube around it.