Clinical application of ultra high field magnetic resonance imaging and spectroscopy

超高场磁共振成像和光谱学的临床应用

• 批准号: 02044124
• 负责人: NARUSE Shoji
• 金额: $ 4.54万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02044124/
• 关键词: Magnetic resonance imaging (MRI); Magnetic resonance spectrum (MRS); Ultra-high field; Chemical shift imaging (CSI); Diffusion weighted image; Cerebral infarction; Brain edema; Lactate; 化学シフト画像(CSI); ^1HーCSI

The possibility and problems of-obtaining VRI and MRS using a high field system were examined from the basic and technical point of view. The first subject was to design the most appropriate method for localized spectra by using an experimental machine for Animal use (4.7 T and 7.0 T). As the result, the chemical shift imaging (CSI) method is best both for ^1H- and ^<31>P-MRS. According to this result, the second was decided to develop. the ^1H-CSI by resolving various problems as follows. The pulse sequence was designed to get good spectra from small voxels with good localization and with good water suppression The eddy current artifact was compensated by adjusting the dephasing and rephasing gradients. The software for data processing were designed to be that the baseline and phase distortions were corrected automatically and the metabolite mapping was carried out by using the curve-fitted data for each peak. Thus, spectra of 256 voxels with a size of 2.5x2.5x2.5 mm each were obtaine … More d within 50 minutes in the experimental system. In the spectrum of experimentally induced brain ischemia, a N-acetyl aspartate (NAA) peak decreased and a lactate peak increased. The metabolite mapping clearly visualized the changes of the distribution of metabolites in the brain. Since there is still problems in the gradient, system and RF amplifier of the clinical ultra-highs field system, the CSI method was examined by applying to the clinical system now available (1.5 T). As the result, spectra could be obtained from 256 voxels with a sue of lxlx2 cm in the normal and patient brains within 25 minutes. In conclusion, the CSI method is essential for clinical use and it is necessary to continue the research of applying and developing this method for clinical use both in the high-field and ultra-high field systems.The second suiects is to develop a diffusion weighted imaging method on a high field experimental MRI/S sytem. As an experimental brain edema models, cytotoxic and vasogenic brain edema models were examined using a 4.7 T experimental MR machine. The pulse sequence used was a spin echo method with additional motion-probing gradient (MPG) Pulses. Faster diffusion was detected in the white matter parallel to the direction of MPGS. Slower diffusion was detected perpendicular to MPGS. This indicated that the diffusion anisotropy of myelinated axonal fibers was defined in white matter. A Diffusion weighted image is useful to analyse the various brain disorders. By using the ultra-high field MRI/S system, it is supposed to be possible to obtain the spectroscopic diffusion weighted image which will clarifythe diffusion of various metabolites in the tissue. Less

从基础和技术角度探讨了利用高场系统获得VRI和MRS的可能性和问题。第一个主题是通过使用动物用实验机器（4.7 T 和 7.0 T）设计最适合局部光谱的方法。结果，化学位移成像(CSI)方法对于^ 1 H-和^ 31 P-MRS都是最好的。根据这个结果，决定开发第二个。 ^1H-CSI 通过解决以下各种问题。脉冲序列被设计为从小体素获得良好的光谱，具有良好的定位和良好的水抑制。通过调整移相和重聚相梯度来补偿涡流伪影。数据处理软件设计为自动校正基线和相位失真，并使用每个峰的曲线拟合数据进行代谢物作图。因此，实验系统在 50 分钟内获得了 256 个尺寸为 2.5x2.5x2.5 mm 的体素的光谱。在实验诱导的脑缺血谱中，N-乙酰天冬氨酸（NAA）峰值降低，乳酸峰值增加。代谢物图谱清楚地可视化了大脑中代谢物分布的变化。由于临床超高场系统的梯度、系统和射频放大器仍然存在问题，因此将CSI方法应用于现有的临床系统（1.5T）进行检验。结果，可以在 25 分钟内从正常人和患者大脑中的 256 个体素（尺寸为 1x1x2 cm）获得光谱。总之，CSI方法对于临床应用至关重要，有必要继续研究在高场和超高场系统中应用和开发该方法的临床应用。第二个目标是开发一种在高场实验MRI/S系统上的扩散加权成像方法。作为实验性脑水肿模型，使用4.7T实验MR机检查细胞毒性和血管源性脑水肿模型。使用的脉冲序列是带有附加运动探测梯度（MPG）脉冲的自旋回波方法。在与 MPGS 方向平行的白质中检测到更快的扩散。垂直于 MPGS 检测到较慢的扩散。这表明有髓轴突纤维的扩散各向异性是在白质中定义的。弥散加权图像可用于分析各种脑部疾病。通过使用超高场MRI/S系统，有望获得光谱扩散加权图像，从而阐明组织中各种代谢物的扩散情况。较少的

项目成果

成瀬 昭二: " ^1HーChemical Shift imaging(CSI)法の臨床応用。" Pharma Medica. 10. 165-172 (1991)

Shoji Naruse：“^1H 化学位移成像 (CSI) 方法的临床应用。”Pharma Medica。10. 165-172 (1991)

Shoji NARUSE, Chuzo TANAKA, Seiichi FURUYA: "Topics of diagnostic imaging of cancer ; MRS" KARIKINOS. 4. 1360-1369 (1991)

Shoji NARUSE、Chuzo TANAKA、Seiichi FURUYA：“癌症诊断成像主题；MRS”KARIKINOS。

成瀬 昭二: "脳MRSと代謝情報:正常と病態、 ^1MRSと ^<1H>ーCSI" 日本臨床. 49. 1645-1655 (1991)

Shoji Naruse：“脑 MRS 和代谢信息：正常和病理条件，^1MRS 和 ^<1H>-CSI”日本临床研究 49. 1645-1655 (1991)。

NARUSE,Shoji: "Effects of atrial natriuretic peptide on ishchemic brain edema in rats evaluated by proton magnetic resonance method" Stroke. 22. 61-65 (1991)

NARUSE，Shoji：“通过质子磁共振方法评估心房钠尿肽对大鼠缺血性脑水肿的影响”中风。

Shoji NARUSE, Chuzo TANAKA: "Metabolism studied by magnetic resonance spectroscopy in brain : Normal and Abnormal ; ^1H-MRS and ^1H-CSI" Nihon Rinshou. 49. 1645-1655 (1991)

Shoji NARUSE、Chuzo TANAKA：“通过磁共振波谱研究大脑中的代谢：正常和异常；^1H-MRS 和 ^1H-CSI”Nihon Rinshou。