Analysis of mechanism for neuronal regeneration in damaged brain by using multi-modality MRI methods
多模态MRI方法分析受损脑神经元再生机制
基本信息
- 批准号:14570873
- 负责人:
- 金额:$ 2.24万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2002
- 资助国家:日本
- 起止时间:2002 至 2003
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We have developed multi-modality magnetic resonance imaging (MRI) techniques for analysis of neuronal regeneration in damaged brain. Those are; (1)Fiber tracking imaging method by using diffusion tensor images obtained from ultra-fast diffusion weighted imaging; (2)Neuronal activation imaging method by using dynamic-activity manganese-dependent contrast MRI (DAIM MRI). This method depends on the theory that Mn ion can enter into neuronal cell in conjunction with Ca ion during the neuronal activation; (3)Two dimensional MR spectroscopy (2D-MRS) by which various brain metabolites can be analyzed precisely in damaged brain; (4)Perfusion imaging using arterial spin tagging method, (4)Improvement of functional MRI (fMRI) on ultra-high field magnet. MRI devices used were experimental MRI machines (4.7T Bruker Biospec and 7.0T Varian INOVA300SWB) and a whole body MRI machine for human (1.5T GE Signa Horizon,1.5T Siemens Symphony and 3.0T GE Signa Horizon).In fiber tracking imaging method, thr … More ee dimensional distribution of fiber orientation ~vas clearly demonstrated by the images based on diffusion tensor direction. Disconnection of fiber was demonstrated in cases of cerebral infarction. In DAIM MRI method, neuronal fibers were clearly demonstrated in rat olfactory grove, optic nerve and optic radiation. Also the six cortical layers were clearly demonstrated by this method. This method is useful to detect the neuronal orientation and brain structure directly based on the nerve cell activation. In 2D-MRS,2D-JPRESS and 2D-COSY were developed on 1.5T and 3.0T clinical MRI devices. Brain metabolites which could not be detected by conventional MRS method were obtained by those 2D-MRS method, such as glutamine/glutamate, glutathione, threonine and GABA. 2D-MRS is useful to examine the viability of damaged brain from the metabolic point of view. The perfusion imaging using arterial spin tagging method was useful to detect the cerebral blood flow change non-invasively, and the combination with diffusion weighted imaging is useful to know the viablity of penumbra region in cerebral infarction.In conclusion, the multi-modality MR methods are unique and useful to examine the regeneration of damaged brain tissue and nerve cell function non-invasively. Since there are still more techniques in MRI methods to evaluate the brain function and metabolism, further research should be continued. Less
我们开发了多模态磁共振成像(MRI)技术来分析受损大脑中的神经元再生。这些都是;(1)利用超快速扩散加权成像获得的扩散张量图像进行光纤跟踪成像方法;(2)动态活性锰依赖对比MRI (DAIM MRI)神经元激活成像方法。该方法基于神经元活化过程中Mn离子与Ca离子结合进入神经元细胞的理论;(3)二维磁共振光谱(2D-MRS),可以精确分析损伤脑内的各种脑代谢物;(4)动脉自旋标记法灌注成像;(4)超高场磁体功能磁共振成像(fMRI)的改进。MRI设备为实验MRI机(4.7T Bruker Biospec和7.0T Varian INOVA300SWB)和人体全身MRI机(1.5T GE Signa Horizon,1.5T Siemens Symphony和3.0T GE Signa Horizon)。在光纤跟踪成像方法中,基于扩散张量方向的图像清晰地显示了光纤取向的更多维度分布。在脑梗死的病例中,纤维断裂被证实。大鼠嗅丛、视神经和视辐射中可见清晰的神经纤维。该方法还清晰地显示了皮层的6层。该方法可以根据神经细胞的激活情况直接检测神经元的方向和大脑结构。2D-MRS、2D-JPRESS和2D-COSY分别在1.5T和3.0T的临床MRI设备上进行开发。采用2D-MRS方法获得了常规MRS法检测不到的脑代谢物,如谷氨酰胺/谷氨酸、谷胱甘肽、苏氨酸和GABA。2D-MRS从代谢的角度检查受损脑的生存能力是有用的。动脉自旋标记法灌注成像有助于无创检测脑血流变化,与弥散加权成像结合有助于了解脑梗死半暗区生存能力。综上所述,多模态MR方法是一种独特的、有用的无创检测损伤脑组织和神经细胞功能再生的方法。由于MRI方法中评估脑功能和代谢的技术还比较多,需要进一步的研究。少
项目成果
期刊论文数量(42)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Ebisu T, Mori Y, Katsuta K, Fujikawa A, Aoki I, Umeda M, Nanise S: "Neuroprotective effects of an immunosuppressant agent on diffusion/perfusion mismatch in transient focal ischemia"Magnetic Resonance in Medicine. 52(In press). (2004)
Ebisu T、Mori Y、Katsuta K、Fujikawa A、Aoki I、Umeda M、Nanise S:“免疫抑制剂对短暂性局灶性缺血中扩散/灌注不匹配的神经保护作用”医学磁共振。
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Ebisu T, Mori Y, Katsuta K, Fujikawa A, Aoki I, Umeda M, Naruse S: "Neuroprotective effects of an immunosuppressant agent on diffusion/perfusion mismatch in transient focal ischemia"Magnetic Resonance in Medicine. 51(in press). (2004)
Ebisu T、Mori Y、Katsuta K、Fujikawa A、Aoki I、Umeda M、Naruse S:“免疫抑制剂对短暂性局灶性缺血中扩散/灌注不匹配的神经保护作用”医学磁共振。
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Thomas AI, Hattori N, Umeda M, Sawada T, Naruse S: "Evaluation of two-dimensional L-COSY and JPRESS using a 3T MRI scanner : from phantoms to human brain in vivo"NMR in Biomedicine. 16(5). 245-251 (2003)
Thomas AI、Hattori N、Umeda M、Sawada T、Naruse S:“使用 3T MRI 扫描仪评估二维 L-COSY 和 JPRESS:从体模到人脑体内”生物医学中的 NMR。
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Aoki I, Ebisu T, Tanaka C, Katsuta K, Fujikawa A, Umeda M, Naruse S: "Detection of the anoxic depolarization of focal ischemia using manganese-enhanced MRI."Magnetic Resonance in Medicine. 50・1. 7-12 (2003)
Aoki I、Ebisu T、Tanaka C、Katsuta K、Fujikawa A、Umeda M、Naruse S:“使用锰增强 MRI 检测局灶性缺血的缺氧去极化。”医学中的磁共振 50・1。 12 (2003)
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Saito M, Umeda M, Fujiwara K, Kakimoto N, Tanaka C, Murakami S, Furukawa S.: "Functional analysis of human parotid gland in vivo using the (1)H MRS MT effect."NMR Biomed. 15(6). 416-421 (2002)
Saito M、Umeda M、Fujiwara K、Kakimoto N、Tanaka C、Murakami S、Furukawa S.:“利用 (1) H MRS MT 效应对人腮腺进行体内功能分析。”NMR Biomed。
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NARUSE Shoji其他文献
NARUSE Shoji的其他文献
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{{ truncateString('NARUSE Shoji', 18)}}的其他基金
Analysis of the mechanism of neuronal regeneration by using multi-nuclei magnetic resonance methods with molecular imaging of brain function
脑功能分子影像多核磁共振方法分析神经元再生机制
- 批准号:
20591455 - 财政年份:2008
- 资助金额:
$ 2.24万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of molecular imaging of brain function by using multi-nuclei magnetic resonance method and its application to analysis of cerebral disorders
多核磁共振脑功能分子影像技术的发展及其在脑疾病分析中的应用
- 批准号:
18591362 - 财政年份:2006
- 资助金额:
$ 2.24万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
In vivo analysis of mechanism for neuronal regeneration in damaged brain by using multi-nuclear, multi-modality MRI methods
利用多核、多模态 MRI 方法体内分析受损脑神经元再生机制
- 批准号:
16591216 - 财政年份:2004
- 资助金额:
$ 2.24万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of multi-modality magnetic resonance methods for cerebral blood flow, metabolism and brain function on ultra-high magnetic field and its clinical application
超高磁场下脑血流、代谢及脑功能多模态磁共振方法开发及临床应用
- 批准号:
12670897 - 财政年份:2000
- 资助金额:
$ 2.24万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of Magnetic Resonance Imaging of Neuronal activity and its application to functional brain imaging
神经元活动磁共振成像的发展及其在脑功能成像中的应用
- 批准号:
09557072 - 财政年份:1997
- 资助金额:
$ 2.24万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Application of cerebral blood flow and metabolism imaging with multi-nuclear, multi-modality MRI techniques to cerebral
多核多模态MRI技术脑血流及代谢成像在脑血管病中的应用
- 批准号:
09671438 - 财政年份:1997
- 资助金额:
$ 2.24万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of spectroscopic diffusion weighted imaging of metabolites in the brain
脑内代谢物光谱扩散加权成像的发展
- 批准号:
04557063 - 财政年份:1992
- 资助金额:
$ 2.24万 - 项目类别:
Grant-in-Aid for Developmental Scientific Research (B)
Clinical application of ultra high field magnetic resonance imaging and spectroscopy
超高场磁共振成像和光谱学的临床应用
- 批准号:
02044124 - 财政年份:1990
- 资助金额:
$ 2.24万 - 项目类别:
Grant-in-Aid for international Scientific Research
Trial of Magnetic Resonance Imaging (MRI) of neurotransmitter in the brain
大脑神经递质的磁共振成像(MRI)试验
- 批准号:
62870059 - 财政年份:1987
- 资助金额:
$ 2.24万 - 项目类别:
Grant-in-Aid for Developmental Scientific Research
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