Application of cerebral blood flow and metabolism imaging with multi-nuclear, multi-modality MRI techniques to cerebral

多核多模态MRI技术脑血流及代谢成像在脑血管病中的应用

基本信息

  • 批准号:
    09671438
  • 负责人:
  • 金额:
    $ 1.92万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    1997
  • 资助国家:
    日本
  • 起止时间:
    1997 至 1998
  • 项目状态:
    已结题

项目摘要

We have developed multi-nuclear and multi-modality magnetic resonance microscopic imaging (MRI) techniques for analysis of brain functions and various cerebral disorders, both experimentally and clinically. These methods are ; (1) Fast Chemical Shift Imaging (CSI) method for detecting various metabolite in the brain, (2) Diffusion-weighted imaging using ultrafast MRI (EPI-DWI), (3) Perfusion Imaging using arterial spin tagging method and (4) Functional MRI using ultrafast MRI.In magnetic resonance spectroscopy (MRS), various metabolites in the brain were detected and their distribution was visualized by the CSI method. Energy metabolism and phospholipid metabolism can be examined by ^<31>P-MRS.The increase of phosphomonoesters in brain tumors and infant brain indicates the changes of phospholipid metabolism. Decreased phosphocreatine and increased lactate in cerebral infarction indicate the impairment of aerobic metabolism. Amino acids, choline, creatine and lactate can be detected by … More ^1H-MRS.The decrease of N-acetyl aspartate (NAA) in brain tumors, degenerative diseases and cerebral infarction indicates the loss of neurons. Increased lactate was observed in hypoxic cell fractions in malignant tumors and infarction. In the EPI-DWI, cerebral infarction is detected at an ultra-acute stage such as 30 minutes after the onset. The EPI-DWI would be used as a first choice for detecting cerebral vascular diseases. The perfusion imaging using arterial spin tagging method (FAIR) is useful to detect the realative changes in cerebral blood flow, but it still requires more sensitivity for a clinical application using 1.5 T system. At moment, the perfusion imagin using contrast material is practical to know the cerebral hemodynamics using MRI.The combination of EPI-DWI and Perfusion Imaging can possibly indicate the reversibility of damaged brain tissue. In functional MRI (fMRI), an increase of signal intensity was observed in the primary cortical area corresponding to each activation task such as finger movements, photic stimulation and hearing words. The fMRI was also obtained by complex tasks such as imagination. Fast fMRI can be used to detect the time deference of activation in primary and secondary motor cortex. Although there are still some problems in fMRI, it is useful for evaluating brain function non-invasively with highly temporal and spatial resolution. The multi-modality MR methods are unique and useful methods to examine the brain metabolism and function non-invasively and to examine pathophysiology of various cerebral disorders. In this sense, further research should be continued. Less
我们已经开发了多核和多模态磁共振显微成像(MRI)技术,用于分析大脑功能和各种大脑疾病,无论是实验还是临床。这些方法是;(1)用于检测脑中各种代谢物的快速化学位移成像(CSI)方法,(2)使用超快MRI的扩散加权成像(EPI-DWI),(3)使用动脉自旋标记法的灌注成像(Perfusion Imaging)和(4)使用超快MRI的功能MRI。~ 1 P-MRS可检测能量代谢和磷脂代谢<31>,脑肿瘤和婴儿脑组织中磷酸单酯的增加反映了磷脂代谢的改变。脑梗塞时磷酸肌酸减少、乳酸增加提示有氧代谢障碍。氨基酸、胆碱、肌酸和乳酸可以通过 ...更多信息 脑肿瘤、退行性疾病和脑梗塞中N-乙酰天冬氨酸(NAA)的减少表明神经元的丢失。在恶性肿瘤和梗死的缺氧细胞组分中观察到乳酸增加。在EPI-DWI中,在超急性期(例如发病后30分钟)检测到脑梗死。EPI-DWI可作为诊断脑血管疾病的首选方法。采用动脉自旋标记法(FAIR)的灌注成像可用于检测脑血流的相关变化,但对于1.5T系统的临床应用仍有较高的灵敏度要求。目前,利用MRI了解脑血流动力学的灌注成像是可行的,EPI-DWI与灌注成像的结合有可能提示脑组织损伤的可逆性。在功能性MRI(fMRI)中,在对应于每个激活任务(如手指运动、光刺激和听单词)的初级皮层区域中观察到信号强度的增加。功能磁共振成像也通过想象等复杂任务获得。快速fMRI可以检测初级和次级运动皮层激活的时间差异。虽然目前功能磁共振成像技术还存在一些问题,但它具有很高的时间和空间分辨率,是一种无创的脑功能评价方法。多模态MR方法是无创检查脑代谢和功能以及检查各种脑疾病的病理生理学的独特而有用的方法。从这个意义上说,应继续进行进一步的研究。少

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Ebisu T, et al: "Hemorrhagic and nonhemorrhagic stroke : Diagnosis with diffusion-weighted and T2-weighted echo planar MR imaging"Radiology. 203. 823-828 (1997)
Ebisu T 等人:“出血性和非出血性中风:利用弥散加权和 T2 加权回波平面 MR 成像进行诊断”放射学。
  • DOI:
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    0
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  • 通讯作者:
Shoji NARUSE et al.: "Flow velocity of the cortical rein and its effect on functional brain MRI at 1st" J Magn Reson Imag.7. 347-352 (1997)
Shoji NARUSE 等人:“皮质缰绳的流速及其对第一次功能性脑 MRI 的影响”J Magn Reson Imag.7。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
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  • 通讯作者:
Naruse S, et al.: "Functional MRI. (in Japanese)"Igakuno-Ayumi. 181(9). 626 (1997)
Naruse S 等人:“功能性 MRI。(日语)”Igakuno-Ayumi。
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  • 影响因子:
    0
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Osamu Kizu, et al.: "Application of proton chemical shift imaging in monitoring of gamma knife radiosurgery on brain tumors." Magnetic Resonance Imaging. 16(1). 197-204 (1998)
Osamu Kizu 等人:“质子化学位移成像在监测脑肿瘤伽玛刀放射外科手术中的应用。”
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
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  • 通讯作者:
Naruse S, et al.: "Echo Planar Diffusion Weighted Imaging (in Japanese)"Nihonn-Rinshou. 5. 1617-1619 (1997)
Naruse S 等人:“回波平面扩散加权成像(日语)”Nihonn-Rinshou。
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    0
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NARUSE Shoji其他文献

NARUSE Shoji的其他文献

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{{ truncateString('NARUSE Shoji', 18)}}的其他基金

Analysis of the mechanism of neuronal regeneration by using multi-nuclei magnetic resonance methods with molecular imaging of brain function
脑功能分子影像多核磁共振方法分析神经元再生机制
  • 批准号:
    20591455
  • 财政年份:
    2008
  • 资助金额:
    $ 1.92万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Development of molecular imaging of brain function by using multi-nuclei magnetic resonance method and its application to analysis of cerebral disorders
多核磁共振脑功能分子影像技术的发展及其在脑疾病分析中的应用
  • 批准号:
    18591362
  • 财政年份:
    2006
  • 资助金额:
    $ 1.92万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
In vivo analysis of mechanism for neuronal regeneration in damaged brain by using multi-nuclear, multi-modality MRI methods
利用多核、多模态 MRI 方法体内分析受损脑神经元再生机制
  • 批准号:
    16591216
  • 财政年份:
    2004
  • 资助金额:
    $ 1.92万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Analysis of mechanism for neuronal regeneration in damaged brain by using multi-modality MRI methods
多模态MRI方法分析受损脑神经元再生机制
  • 批准号:
    14570873
  • 财政年份:
    2002
  • 资助金额:
    $ 1.92万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Development of multi-modality magnetic resonance methods for cerebral blood flow, metabolism and brain function on ultra-high magnetic field and its clinical application
超高磁场下脑血流、代谢及脑功能多模态磁共振方法开发及临床应用
  • 批准号:
    12670897
  • 财政年份:
    2000
  • 资助金额:
    $ 1.92万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Development of Magnetic Resonance Imaging of Neuronal activity and its application to functional brain imaging
神经元活动磁共振成像的发展及其在脑功能成像中的应用
  • 批准号:
    09557072
  • 财政年份:
    1997
  • 资助金额:
    $ 1.92万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Development of spectroscopic diffusion weighted imaging of metabolites in the brain
脑内代谢物光谱扩散加权成像的发展
  • 批准号:
    04557063
  • 财政年份:
    1992
  • 资助金额:
    $ 1.92万
  • 项目类别:
    Grant-in-Aid for Developmental Scientific Research (B)
Clinical application of ultra high field magnetic resonance imaging and spectroscopy
超高场磁共振成像和光谱学的临床应用
  • 批准号:
    02044124
  • 财政年份:
    1990
  • 资助金额:
    $ 1.92万
  • 项目类别:
    Grant-in-Aid for international Scientific Research
Trial of Magnetic Resonance Imaging (MRI) of neurotransmitter in the brain
大脑神经递质的磁共振成像(MRI)试验
  • 批准号:
    62870059
  • 财政年份:
    1987
  • 资助金额:
    $ 1.92万
  • 项目类别:
    Grant-in-Aid for Developmental Scientific Research

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    2014
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In vivo Imaging of a Disease Model in Medaka by 14.1 T MR Microscopy
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