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Trial of Magnetic Resonance Imaging (MRI) of neurotransmitter in the brain

大脑神经递质的磁共振成像（MRI）试验

基本信息

批准号：
62870059
负责人：
NARUSE Shoji
金额：
$ 9.41万
依托单位：
Kyoto Prefectural University of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research
财政年份：
1987
资助国家：
日本
起止时间：
1987 至 1988
项目状态：
已结题

项目摘要

In order to obtain the magnetic resonance spectroscopic imaging (MRSI) of neurotransmitter in the brain, the new technique called SIDAC (spectroscopic imaging by sephasing amplitude change) was transplanted to the ordinary high resolution NMR spectrometer (4.7 T, 9 cm bore, JEOL). Using the system, MRSI of standard solution of lactate and amino acids with high concentration were successfully obtained. However, it was difficult to get MRSI of these compounds with low consentration and from the rat brain. This is due to the problems of low homogeneity in the whole regions of the magnet and the difficulty of rapid changing of gradient magnetic fields. As the second series of experiment, a 2.0 T MRI/S system (100 cm bore, Asahi Medical) was used to get MRSI of standard solution, rabbit brain and human arms. In this experiment also, MRSI could be obtained from the standard solution but not from the rabbit brain and human arms. These problems are attribute to the lacking of appropriate water suppression technique and the difficulties of getting the high homoneity of magnetic field. The water suppression technique used was the pre-saturation at the moment, that could suppress the water signal at the rate of 1/100. To suppress the water signal at the rate of 1/1000 or 1/1000, another thechnique such as 1-3-3-1 method is neccessary to be used and is now going to be examined. So far as using 2.0 T machine, the signal intensity is not strong enough to get MRSI of low content substances practically. From this experiment, it is concluded that MRSI of neurotransmitter in the brain in very important and it is possible to succeed it if the high field magnet such as 4.7 T or more (7.0 T is preferable) is applied.

为了获得脑内神经递质的磁共振波谱成像（MRSI），将一种新技术SIDAC（spectroscopic imaging by sephasing amplitude change）移植到普通的高分辨核磁共振波谱仪（4.7T，9 cm bore，JEOL）上。利用该系统，成功地获得了高浓度乳酸和氨基酸标准溶液的MRSI。但这些化合物的浓度较低，且在大鼠脑内难以得到MRSI。这是由于磁体的整个区域中的低均匀性和梯度磁场的快速变化的困难的问题。作为第二系列实验，使用2.0 T MRI/S系统（100 cm孔径，Asahi Medical）获得标准溶液、兔脑和人手臂的MRSI。在本实验中，也可以从标准品溶液中获得MRSI，但不能从兔脑和人手臂中获得。这些问题的产生是由于缺乏合适的抑水技术和难以获得高的磁场均匀性。此时采用的水抑制技术是预饱和，可以百分之一的抑制水信号。为了抑制1/1000或1/1000的水信号，必须采用另一种技术，如1-3-3-1方法，现在将进行研究。对于2.0T的磁共振成像仪，信号强度不够强，难以实际得到低含量物质的磁共振成像。从该实验得出结论，大脑中神经递质的MRSI是非常重要的，并且如果应用诸如4.7T或更高（优选7.0T）的高场磁体，则有可能成功。