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Study on Guide System Based on the Blood Flow Force for Intravascular Catheter

基于血流力的血管内导管导向系统研究

基本信息

批准号：
05402035
负责人：
NAKAJIMA Naomasa
金额：
$ 13.76万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (A)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1995
项目状态：
已结题

项目摘要

It is usually difficult to guide a catheter safely inside blood vessels. We have devised a guide system based on the fluid force of blood vessel in order to control the direction of advance of a catheter being passed through artery blood vessels with 2-6 mm inner diameter. This system consists of a cylindrical streamer with a 1 mm diameter, 1.5 mm long and 20mum wall thickness, two supporting legs and one filament of 20 mum. Movement of the streamer can be controlled by adjusting the length of the wire. We studied the behavior of the cylindrical streamer by numerical analysis of fluid force, and investigated the cahracteristics of a model system by experiment using a simulator of pulsating blood flow (range of Reynolds number : 71-930, dynamic viscosity : 1-6 mm2/s). We obtained relation between attack angle and dimensionless lift, dimensionless drag and dimensionless lift, and then designed a prototype guide system and succeeded to guide branched vessels of the simulator.A new type of actuator which consists of an eccentric thin silicon rubber tube and deforms spirally by hydraulic pressure was invented to simplify the control of a position and an angle of the streamer, and showed its usefulness in experiment.Also a safety detaching method for endovascular treatment with laser light was invented. We attached the mechanism to the end of a catheter and confirmed its usefulness by experiments on rabbits.

通常很难将导管安全地引导到血管内。我们设计了一种基于血管流体力的导向系统，以控制导管在内径2-6 mm的动脉血管中的前进方向。该系统由直径为1 mm、长为1.5 mm、壁厚为20 μ m的圆柱形拖缆、两个支撑腿和一个20 μ m的灯丝组成。拖缆的移动可以通过调整缆线的长度来控制。本文用流体力学的数值分析方法研究了圆柱形流光的特性，并用脉动血流模拟器（雷诺数范围：71-930，动态粘度范围：1-6 mm ~ 2/s）对模型系统的特性进行了实验研究。得到了攻角与无因次升力、无因次阻力和无因次升力之间的关系，设计了原型导引系统，成功地导引了模拟器的分支船;发明了一种新型的偏心薄硅橡胶管液压致动器，简化了拖缆位置和角度的控制，并在实验中证明了其有效性，同时也为激光血管内治疗提供了一种安全的解脱方法。我们将该机构连接到导管的末端，并通过对兔子的实验证实了其有效性。