Development of Third Generation Biosensors

环境监测用多生物传感器的研制利用固定化微生物在氧电极表面的呼吸变化检测氰化物的生物传感器。重点讨论了河流水质监测的未来应用。对所研制的传感器进行了评价，并与传统方法进行了比较。根据与马蒂教授的小组的讨论，他们在环境监测方面拥有高度复杂的技术，传感器似乎非常有用。多通道生物传感器的研制利用化学发光技术，为使磷酸盐传感器具有更高的灵敏度进行了多次尝试。Coulet教授的研究小组已经使用鲁米诺进行了化学发光的研究，他们的建议很好地满足了我们的目的。气体材料生物传感器的发展光电化学方法对氰化物等气体材料的检测是有效的。利用人造金刚石电极作为生物传感器似乎也是有效的，因为它具有宽的电位窗口而不受水的影响。水质监测传感器的发展利用催化抗体作为一种新的生物传感器似乎非常有趣，而利用遗传算法等计算机辅助方法制备生物功能分子似乎也很有效。

Development of multibiosensor for environmetal monitoringBiosensor for cyanide detectionusing resparatory change of the microbe immobilized on the surface of oxygen electrode. This was focused on the future application of river water monitoring. Evaluation of the sensor developed were performed and the comparison woth conventional method was done. According to the discussion with Prof. Marty's group, who has a highly sofisticated technique on environmental monitoring, the sensor seemed to be very useful.Development of multichannel biosensorsSeveral efforts were tried to have the higher sensitivity of the phosphate sensor using chemiluminescence. Research group of Prof. Coulet has already worked with chemiluminescence using luminol and their advice worked well for our purpose.Development of gaseous materials biosensorsElectrophotochemical approach towards the detection of gaseous materials such as cyanide was concluded as effective for the purpose. The use of artificial diamond electrode for biosensor seemed also effective because of its wide potential window without being affected by water.Development of water quality monitoring sensorsThe use of catalytic antibody for a new biosensor seemed very interesting, and the preparation of bio-functional molecules using computer-aided method such as genetic algorism also seemed effective.