New development of transduction mechanism in chemical senses
化学意义上转导机制的新进展
基本信息
- 批准号:07308049
- 负责人:
- 金额:$ 5.89万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (A)
- 财政年份:1995
- 资助国家:日本
- 起止时间:1995 至 1996
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Various results on olfactory and gustatory receptor mechanisms were obtained.(1) It was found that there is a transduction pathway independent of cAMP and IP3 in olfactory cell. This pathway was independent of Ca, NO and cGMP.It was also found that membrane fluidity changes of turtle olfactory cell affect ability to discriminate odorants, suggesting that lipid layr of olfactory cell membranes in involved in oder reception.(2) It was found that application of low concentration of saccharine to mouse taste cells increased cAMP level and that of high concentration of saccharine increased IP3. The suger response in fly taste cell was suppressed by inhibitors for production of IP3, suggesting that IP3 is involved in sugar reception in fly taste cell. It was also found that bitterness of various substances is suppressed by acidic phospholipids such as phosphatidic acid, phosphatidylinositol and phosphatidylserine. Among these lipids, phosphatidic acid was most effective to suppress bitterness.
嗅觉和味觉受体机制的各种结果。(1)结果发现,在嗅细胞中存在一条不依赖cAMP和IP3的信号转导通路。该通路不依赖于Ca、NO和cGMP,同时还发现嗅细胞膜流动性的变化影响嗅细胞对气味的辨别能力,提示嗅细胞膜脂质层参与了气味的接收。(2)结果发现,低浓度糖精对小鼠味觉细胞的应用增加了cAMP水平,而高浓度糖精则增加了IP 3。果蝇味觉细胞的糖反应被IP3产生抑制剂抑制,提示IP3参与了果蝇味觉细胞的糖接收。还发现各种物质的苦味被酸性磷脂如磷脂酸、磷脂酰肌醇和磷脂酰丝氨酸抑制。在这些脂质中,磷脂酸是最有效的抑制苦味。
项目成果
期刊论文数量(58)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
M.Taniguchi: "Difference in behavior between responses to forskolin and general odorants in turtle vomeronasal organ." Chem.Senses. 21. 763-777 (1996)
M.Taniguchi:“乌龟犁鼻器对毛喉素和一般气味剂的反应之间的行为差异。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
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- 通讯作者:
M.Koganezawa: "The effect of G protein modulators on the labellar taste receptor cells of the fleshfly (Boettcherisca Pergrina)" J.Insect Physiol.43. 225-233 (1997)
M.Koganezawa:“G 蛋白调节剂对肉蝇 (Boettcherisca Pergrina) 标签味觉受体细胞的影响”J.Insect Physiol.43。
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- 发表时间:
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- 影响因子:0
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M. Taniguch: "Intracellular dialysis of cyclic nucleotides induces inward currents in turtle vomeronasal receptor neurons." J. Nearosci. 16・3. 1239-1246 (1996)
M. Taniguch:“环核苷酸的细胞内透析诱导乌龟犁鼻受体神经元的内向电流。”J. Nearosci 16·3(1996)。
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- 发表时间:
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- 影响因子:0
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- 通讯作者:
Y.Katsuragi: "Selective inhibition of bitter taste of various drugs by lipoprotein" Pharm.Res.12. 658-662 (1995)
Y.Katsuragi:“脂蛋白对各种药物苦味的选择性抑制”Pharm.Res.12。
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- 影响因子:0
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- 通讯作者:
H.Nagao: "Effects of adenylyl cyclase-linked neuropeptides on the expression of CNTF-mRNA in cultured glial cells from rat olfactory bulb and cerebral cortex" FEBS Lett.362. 75-79 (1995)
H.Nagao:“腺苷酸环化酶连接的神经肽对大鼠嗅球和大脑皮层培养的神经胶质细胞中 CNTF-mRNA 表达的影响”FEBS Lett.362。
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- 影响因子:0
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KURIHARA Kenzo其他文献
KURIHARA Kenzo的其他文献
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{{ truncateString('KURIHARA Kenzo', 18)}}的其他基金
Factory Automation Control System Designing Method Aiming High reliability and High Productivity of Software
以软件高可靠性和高生产率为目标的工厂自动化控制系统设计方法
- 批准号:
15560227 - 财政年份:2003
- 资助金额:
$ 5.89万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
RARE KEY SUBSTANES OLFACTORY SENSE : IDETIFICATION OF HOME STREAM SUBSTANCES IN SALMON
稀有关键物质嗅觉:三文鱼中原生物质的识别
- 批准号:
12045257 - 财政年份:2000
- 资助金额:
$ 5.89万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
Molecular discrimination and transduction in singe olfactory and vomeronasal receptor cells
单一嗅觉和犁鼻受体细胞的分子辨别和转导
- 批准号:
09480169 - 财政年份:1997
- 资助金额:
$ 5.89万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of safety inhibitor which selectively masks receptor sites for bitter substances
开发选择性掩盖苦味物质受体位点的安全抑制剂
- 批准号:
09557185 - 财政年份:1997
- 资助金额:
$ 5.89万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
A new transduction mechanism of chemoreceptor cells and cloning of receptor protein
化学感受细胞新转导机制及受体蛋白克隆
- 批准号:
07457533 - 财政年份:1995
- 资助金额:
$ 5.89万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Masking of bitter taste and smell of drugs by protein-lipid complex prepared from materials for foods
用食品材料制备的蛋白质-脂质复合物掩盖药物的苦味和气味
- 批准号:
06557119 - 财政年份:1994
- 资助金额:
$ 5.89万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Cloning of genes encoding putative taste receptor proteins
编码假定味觉受体蛋白的基因的克隆
- 批准号:
05454627 - 财政年份:1993
- 资助金额:
$ 5.89万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
Preparation of artificial membrane sensor which responds to various odorants
响应多种气味的人工膜传感器的制备
- 批准号:
01870096 - 财政年份:1989
- 资助金额:
$ 5.89万 - 项目类别:
Grant-in-Aid for Developmental Scientific Research
Identification and Transduction Mechanisms in Chemoreceptor Cells
化学感受器细胞的识别和转导机制
- 批准号:
63480496 - 财政年份:1988
- 资助金额:
$ 5.89万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
Mechanisms of stimuli discrimination and transduction in gustatory and olfactory cells
味觉和嗅觉细胞的刺激辨别和转导机制
- 批准号:
60480457 - 财政年份:1985
- 资助金额:
$ 5.89万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
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