Development of safety inhibitor which selectively masks receptor sites for bitter substances
开发选择性掩盖苦味物质受体位点的安全抑制剂
基本信息
- 批准号:09557185
- 负责人:
- 金额:$ 7.87万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:1997
- 资助国家:日本
- 起止时间:1997 至 1998
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In a previous study, we found that lipoprotein composed of phosphatidic acid and blactoglobulin selectively inhibits bitterness. The lipoprotein binds to micovilli membranes of taste cells and masks receptor sites for bitter substances. For practical use of bitterness inhibitor, an inhibitor carrying no protein is desirable in points of stability and cost. Hence we examined bitterness-inhibitory activity of various phospholipids and found that phosphatidic acid, phosphatidyl inositole and phosphatidyl serine have activity to suppress bitterness. Among these phospholipids, phosphatidic acid had the highest activity.We also examined the effects of lecithin fraction containing phosphatidic acid in high content on bitterness and found that the fraction has sufficient activity to suppress bitterness. The fraction suppressed bitterness of various drugs and hydrolyzates of proteins. Coating of tablets of drugs with a small amount of the lecithin fraction sufficiently suppressed bitterness of the drugs. In addition, the fraction suppressed bitterness of polyphenol. Polyphenol is abundantly contained in chocolate. The lecithin fraction has been used to suppress bitterness of chocolate which contains polyphenol in high content.
在之前的研究中,我们发现由磷脂酸和乳球蛋白组成的脂蛋白选择性地抑制苦味。脂蛋白结合到味觉细胞的微孔膜上,并掩盖苦味物质的受体位置。对于苦味抑制剂的实际应用,从稳定性和成本的角度考虑,不携带蛋白质的抑制剂是可取的。因此,我们考察了各种磷脂的苦味抑制活性,发现磷脂酸、磷脂酰肌醇和磷脂酰丝氨酸具有抑制苦味的活性。在这些磷脂中,磷脂酸的活性最高。我们还考察了高含量磷脂酸的卵磷脂部分对苦味的影响,发现该部分具有足够的抑制苦味的活性。该组分对多种药物和蛋白质水解物的苦味有抑制作用。用少量卵磷脂部分包衣的药片充分抑制了药物的苦味。此外,该组分还能抑制多酚的苦味。巧克力中含有丰富的多酚。卵磷脂被用来抑制巧克力的苦味,因为巧克力中含有高含量的多酚。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Y.Katsuragi: "Specific inhibitor for bitter taste:inhibition of frog taste nerve responses and human taste sensation to bitter stimuli" Brain.Res.Protocols.1. 292-298 (1997)
Y.Katsuragi:“苦味的特异性抑制剂:抑制青蛙味觉神经反应和人类对苦味刺激的味觉”Brain.Res.Protocols.1。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Katsuragi, Y.: "Specific inhibitor for bitter taste: inhibition of frog taste nerve responses and human taste sensation to bitter stimuli"Brain Res. Protocols. 1. 292-298 (1997)
Katsuragi, Y.:“苦味的特异性抑制剂:抑制青蛙味觉神经反应和人类对苦味刺激的味觉”Brain Res。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
桂木能久: "苦味マスキング剤" 化学総説. 40. 84-89 (1999)
Yoshihisa Katsuragi:“苦味掩蔽剂”化学评论。40. 84-89 (1999)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
栗原堅三: "味覚のしくみ" 化学総説. 40. 3-17 (1999)
Kenzo Kurihara:“味觉机制”化学评论。40. 3-17 (1999)
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- 影响因子:0
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KURIHARA Kenzo其他文献
KURIHARA Kenzo的其他文献
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{{ truncateString('KURIHARA Kenzo', 18)}}的其他基金
Factory Automation Control System Designing Method Aiming High reliability and High Productivity of Software
以软件高可靠性和高生产率为目标的工厂自动化控制系统设计方法
- 批准号:
15560227 - 财政年份:2003
- 资助金额:
$ 7.87万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
RARE KEY SUBSTANES OLFACTORY SENSE : IDETIFICATION OF HOME STREAM SUBSTANCES IN SALMON
稀有关键物质嗅觉:三文鱼中原生物质的识别
- 批准号:
12045257 - 财政年份:2000
- 资助金额:
$ 7.87万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
Molecular discrimination and transduction in singe olfactory and vomeronasal receptor cells
单一嗅觉和犁鼻受体细胞的分子辨别和转导
- 批准号:
09480169 - 财政年份:1997
- 资助金额:
$ 7.87万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
New development of transduction mechanism in chemical senses
化学意义上转导机制的新进展
- 批准号:
07308049 - 财政年份:1995
- 资助金额:
$ 7.87万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
A new transduction mechanism of chemoreceptor cells and cloning of receptor protein
化学感受细胞新转导机制及受体蛋白克隆
- 批准号:
07457533 - 财政年份:1995
- 资助金额:
$ 7.87万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Masking of bitter taste and smell of drugs by protein-lipid complex prepared from materials for foods
用食品材料制备的蛋白质-脂质复合物掩盖药物的苦味和气味
- 批准号:
06557119 - 财政年份:1994
- 资助金额:
$ 7.87万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Cloning of genes encoding putative taste receptor proteins
编码假定味觉受体蛋白的基因的克隆
- 批准号:
05454627 - 财政年份:1993
- 资助金额:
$ 7.87万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
Preparation of artificial membrane sensor which responds to various odorants
响应多种气味的人工膜传感器的制备
- 批准号:
01870096 - 财政年份:1989
- 资助金额:
$ 7.87万 - 项目类别:
Grant-in-Aid for Developmental Scientific Research
Identification and Transduction Mechanisms in Chemoreceptor Cells
化学感受器细胞的识别和转导机制
- 批准号:
63480496 - 财政年份:1988
- 资助金额:
$ 7.87万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
Mechanisms of stimuli discrimination and transduction in gustatory and olfactory cells
味觉和嗅觉细胞的刺激辨别和转导机制
- 批准号:
60480457 - 财政年份:1985
- 资助金额:
$ 7.87万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
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