Development of re-entrant type hyperthermia system for many different kinds of deep tumor

多种深部肿瘤折返式热疗系统的研制

• 批准号: 16390345
• 负责人: KATO Kazuo
• 金额: $ 7.55万
• 依托单位: Meiji University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390345/
• 关键词: hyperthermia; deep tumor; resonant mode; 3-D finite element method; resonant cavity; resonant frequency; noncontact; leaked electromagnetic field; 非接触加温; 加温パターン; 漏れ電界; 臨床試験; 糖尿病; 非接触深部加温; 寒天ファントム; 環境; 漏れ電磁波; 深部加温; 多種部位; 形状可変空胴共振器; インピー

In this research, a new re-entrant type hyperthermia system was developed to heat many different kinds of deep tumor without contact. Below, the main results of this research are shown.(1) The electromagnetic field and temperature distributions inside the cavity were estimated by 3-D FEM. From these results, it was shown that the proposed heating method was useful for deep tumor hyperthermia.(2) The re-entrant resonant cavity type hyperthermia system for deep tumors was designed and constructed based on the computer simulations.・Developed system consists of a cavity, impedance matching unit, an RF amplifier, an antenna, a computer.・From the results of computer simulations and experimental heating, it was possible to heat the deep tumor of about 2-5cm in diameter by using the different resonance modes (TM010 and TM012-like-modes) without contact.・Moving the position of the object, the position of maximum temperature could be controlled.・Comparing the computer simulation and the experimental results, resonant frequencies agreed with each other with an error of 1% or less, and temperature distributions agreed with each other with an error of 10%.(3) The influence of electromagnetic waves is a social big problem. Leaked electromagnetic field of the developed system hardly has bad influence on the circumferenceIt was found that the proposed heating system could be applicable to heat many different kinds of tumors, noncontact, corresponding to the size and that position where it occurred.

本研究开发了一种新型的再入式热疗系统，可对多种深部肿瘤进行非接触式热疗。下面是这项研究的主要成果。(1)利用三维有限元法计算了腔体内的电磁场和温度分布。从这些结果可以看出，所提出的加热方法对于肿瘤深部热疗是有用的。(2)在计算机模拟的基础上，设计并构建了一种用于深部肿瘤热疗的再入式谐振腔系统。系统由谐振腔、阻抗匹配单元、射频放大器、天线、计算机组成。根据计算机模拟和实验加热的结果，可以通过使用不同的谐振模式（TM 010和TM 012-like模式）无接触地加热直径约2-5cm的深部肿瘤。·移动物体的位置，可以控制最高温度的位置。·将计算机模拟结果与实验结果进行比较，谐振频率与误差在1%以内，温度分布与误差在10%以内。(3)电磁波的影响是一个社会大问题。11所研制的系统的泄漏电磁场几乎不对周围产生不良影响。研究发现，所提出的加热系统可以适用于加热许多不同类型的肿瘤，非接触，对应于大小和发生的位置。

项目成果

Development of the re-entrant type resonant cavity applicator for brain tumor hyperthermia -Experimental heating results -

用于脑肿瘤热疗的凹入式谐振腔治疗器的开发-实验加热结果-

• 发表时间: 2006
• 期刊: Proc. of the 28^<th> Annual International Conference of the IEEE EMBS EMBC2006
• 作者: T.Yabuhara;K.Kato;K.Tsuchiya;et al.
• 通讯作者: et al.

脳腫瘍の非接触温熱治療を目的とした空胴共振器アプリケータの設計・試作

用于脑肿瘤非接触式热处理的空腔谐振器涂抹器的设计和原型

• 发表时间: 2006
• 期刊: 日本機械学会第18回バイオエンジニアリング講演会 講演論文集 No.05-66
• 作者: 高橋慶彦;加藤和夫;他3名
• 通讯作者: 他3名

Improvement of the resonant cavity applicator for brain tumor Hyperthermia -Computer simulation results-

脑肿瘤热疗谐振腔治疗器的改进-计算机模拟结果-

• 发表时间: 2005
• 期刊: Proceedings of the 2005 IEEE EMBC'05
• 作者: T.Shigihara;K.kato;K.Tsuchiya;et al.
• 通讯作者: et al.

深部癌の非接触温熱治療を目的とした空胴共振器アプリケータの設計・試作(第3報,試作加温システムによる人体形状寒天ファントムおよび動物の加温実験)

用于深部癌症非接触式热处理的腔体谐振器涂抹器的设计和原型（第三次报告，使用原型加热系统的人形琼脂模型和动物加热实验）

• 发表时间: 2004
• 期刊: 設計工学会誌 39・11
• 作者: 加藤和夫;和田森直;松田甚一;高橋英明;宇塚岳夫;田中隆一
• 通讯作者: 田中隆一

Design and Construction of Resonant Cavity Applicater for Brain Tumor Hyperthermia Treatment without Contanct

脑肿瘤非接触热疗共振腔施热器的设计与构建

• 发表时间: 2006
• 期刊: Proc. of the 28^<th> Annual International Conference of the IEEE EMBS EMBC2006
• 作者: Y.Takahashi;K.Kato;K.Tsuchiya;et al.
• 通讯作者: et al.