Development of re-entrant type hyperthermia system for many different kinds of deep tumor

多种深部肿瘤折返式热疗系统的研制

• 批准号: 16390345
• 负责人: KATO Kazuo
• 金额: $ 7.55万
• 依托单位: Meiji University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390345/
• 关键词: hyperthermia; deep tumor; resonant mode; 3-D finite element method; resonant cavity; resonant frequency; noncontact; leaked electromagnetic field; 非接触加温; 加温パターン; 漏れ電界; 臨床試験; 糖尿病; 非接触深部加温; 寒天ファントム; 環境; 漏れ電磁波; 深部加温; 多種部位; 形状可変空胴共振器; インピー

In this research, a new re-entrant type hyperthermia system was developed to heat many different kinds of deep tumor without contact. Below, the main results of this research are shown.(1) The electromagnetic field and temperature distributions inside the cavity were estimated by 3-D FEM. From these results, it was shown that the proposed heating method was useful for deep tumor hyperthermia.(2) The re-entrant resonant cavity type hyperthermia system for deep tumors was designed and constructed based on the computer simulations.・Developed system consists of a cavity, impedance matching unit, an RF amplifier, an antenna, a computer.・From the results of computer simulations and experimental heating, it was possible to heat the deep tumor of about 2-5cm in diameter by using the different resonance modes (TM010 and TM012-like-modes) without contact.・Moving the position of the object, the position of maximum temperature could be controlled.・Comparing the computer simulation and the experimental results, resonant frequencies agreed with each other with an error of 1% or less, and temperature distributions agreed with each other with an error of 10%.(3) The influence of electromagnetic waves is a social big problem. Leaked electromagnetic field of the developed system hardly has bad influence on the circumferenceIt was found that the proposed heating system could be applicable to heat many different kinds of tumors, noncontact, corresponding to the size and that position where it occurred.

在本研究中，研制了一种新型折返式热疗系统，用于对多种不同类型的深部肿瘤进行无接触加热。本文的主要研究成果如下：(1)采用三维有限元方法计算了腔体内部的电磁场和温度分布。在计算机模拟的基础上，设计并搭建了折返式共振腔式深部肿瘤热疗系统。·研制的系统由腔体、阻抗匹配单元、射频放大器、天线、计算机组成。从计算机模拟和实验加热的结果来看，使用不同的共振模式(TM010和TM012类模式)可以无接触地加热直径约2-5 cm的深部肿瘤。·移动物体的位置，可以控制最高温度的位置。(3)电磁波的影响是一个很大的社会问题。实验发现，该加热系统可适用于多种肿瘤的非接触式加热，且与肿瘤的大小和发生部位相对应。

项目成果

Development of the re-entrant type resonant cavity applicator for brain tumor hyperthermia -Experimental heating results -

用于脑肿瘤热疗的凹入式谐振腔治疗器的开发-实验加热结果-

• 发表时间: 2006
• 期刊: Proc. of the 28^<th> Annual International Conference of the IEEE EMBS EMBC2006
• 作者: T.Yabuhara;K.Kato;K.Tsuchiya;et al.
• 通讯作者: et al.

脳腫瘍の非接触温熱治療を目的とした空胴共振器アプリケータの設計・試作

用于脑肿瘤非接触式热处理的空腔谐振器涂抹器的设计和原型

• 发表时间: 2006
• 期刊: 日本機械学会第18回バイオエンジニアリング講演会 講演論文集 No.05-66
• 作者: 高橋慶彦;加藤和夫;他3名
• 通讯作者: 他3名

Improvement of the resonant cavity applicator for brain tumor Hyperthermia -Computer simulation results-

脑肿瘤热疗谐振腔治疗器的改进-计算机模拟结果-

• 发表时间: 2005
• 期刊: Proceedings of the 2005 IEEE EMBC'05
• 作者: T.Shigihara;K.kato;K.Tsuchiya;et al.
• 通讯作者: et al.

深部癌の非接触温熱治療を目的とした空胴共振器アプリケータの設計・試作(第3報,試作加温システムによる人体形状寒天ファントムおよび動物の加温実験)

用于深部癌症非接触式热处理的腔体谐振器涂抹器的设计和原型（第三次报告，使用原型加热系统的人形琼脂模型和动物加热实验）

• 发表时间: 2004
• 期刊: 設計工学会誌 39・11
• 作者: 加藤和夫;和田森直;松田甚一;高橋英明;宇塚岳夫;田中隆一
• 通讯作者: 田中隆一

Design and Construction of Resonant Cavity Applicater for Brain Tumor Hyperthermia Treatment without Contanct

脑肿瘤非接触热疗共振腔施热器的设计与构建

• 发表时间: 2006
• 期刊: Proc. of the 28^<th> Annual International Conference of the IEEE EMBS EMBC2006
• 作者: Y.Takahashi;K.Kato;K.Tsuchiya;et al.
• 通讯作者: et al.