Signal cording and target net work of spatial disorientation in the brain

大脑空间定向障碍的信号编码和目标网络

• 批准号: 17390462
• 负责人: TAKEDA Noriaki
• 金额: $ 9.28万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17390462/
• 关键词: Spatial disorientation; Motion sickness; Histamine; Histamine HI receptors; hypergravity; pica

We have developed an animal model of motion sickness, using pica as a behavioral index of motion sickness in rats. Rats cannot vomit, but pica, the ingestion of non-nutritive substances such as kaolin (hydrated aluminum silicate), is an illness-response behavior, which is analogous to vomiting. After 2-hours load of 2g hypergravity, rats ate a significant amount of kaolin, indicating that they suffered from motion sickness. The hypergravity-induced kaolin intake was suppressed by mepyramine, an H1 antagonist, but not by zolantizine, an H2 antagonist. A 2-h load of 2g hypergravity also transiently increased the release of histamine in the rat hypothalamus measured by in vivo brain microdialysis. These findings suggested that the activation of the central histaminergic neuron systems after hypergravity induces motion sickness via H1 receptors (H1R).Then, to investigate changes in post-synaptic events in the development of motion sickness, gene expression of H1R in the rat hypothalamus was examined using a real-time PCR method after hypergravity. The expression of H1R mRNA in the rat hypothalamus was significantly increased after 2g hypergravity for 2 hours, indicating an up-regulation of H1R induced by hypergravity. Taken together with the previous finding demonstrating an activation of the histaminergic neurons after hypergravity, the present finding further indicate an amplification of the H1 transmission in the development of motion sickness,. The up-regulation of H1R may contribute to the built up characteristic of motion sickness symptoms, which developed gradually at first and then progressed rapidly.

以异食癖作为大鼠运动病的行为学指标，建立了大鼠运动病动物模型。老鼠不能呕吐，但异食癖，即摄入非营养物质，如高岭土（水合硅酸铝），是一种疾病反应行为，类似于呕吐。在2小时的2g超重力负荷后，大鼠吃了大量的高岭土，表明它们患有运动病。超重力诱导的高岭土摄入量被抑制美托咪胺，一种H1拮抗剂，但不是由zolantizine，一种H2拮抗剂。通过在体脑微透析测量，2小时2g超重负荷也短暂增加了大鼠下丘脑组胺的释放。结果表明，超重后中枢组胺能神经元系统的激活可能通过H1受体（H1R）诱导运动病的发生。2g超重力作用2h后，大鼠下丘脑H1R mRNA表达显著增加，提示超重力可诱导H1R表达上调。与先前的研究结果表明，超重力后组胺能神经元激活，本研究结果进一步表明，在运动病的发展中，H1传递放大。H1R的上调可能与运动病症状的形成有关，运动病症状先逐渐发展，然后迅速发展。

项目成果

Regional difference in corticotropin-releasing factor immunoreactivity in mossy fiber terminals innervating calretinin-immunoreactive unipolar brush cells in vestibulocerebellum of rolling mouse Nagoya

• DOI: 10.1016/j.brainres.2005.09.018
• 发表时间: 2005-11-23
• 期刊: BRAIN RESEARCH
• 影响因子: 2.9
• 作者: Ando, M;Sawada, K;Fukui, Y
• 通讯作者: Fukui, Y

Natural history of benign paroxysmal positional vertigo and efficacy of Epley and Lemtert maneuvers.

良性阵发性位置性眩晕的自然史以及 Epley 和 Lemtert 演习的功效。

• 发表时间: 2006
• 期刊: Otolaryngol Head Neck Surg 135
• 作者: 森野 茂行;他;大森 孝一;Omori K;中村達雄;K.Sekine
• 通讯作者: K.Sekine

Prognosis of inner ear periphery and central vestibular plasticity in sudden deafness with vertigo

• DOI: 10.1177/000348940511401008
• 发表时间: 2005-10-01
• 期刊: ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
• 影响因子: 1.4
• 作者: Kitahara, T;Takeda, N;Kubo, T
• 通讯作者: Kubo, T

Effects of Immersion in virtual reality on posture control

虚拟现实沉浸对姿势控制的影响

• 发表时间: 2005
• 期刊: Neurosci.Lett. 379
• 作者: 森野 茂行;他;大森 孝一;Omori K;中村達雄;K.Sekine;T.Kitahara;M.Ando.;H.Akizuk.
• 通讯作者: H.Akizuk.