The development of a new treatment for taste impairment using difructose as an enhancer of zinc absorption.

使用双果糖作为锌吸收增强剂开发一种新的味觉障碍治疗方法。

• 批准号: 21592194
• 负责人: TAKEDA Noriaki
• 金额: $ 2.91万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592194/
• 关键词: 味覚障害; 亜鉛欠乏; ACE活性比; 亜鉛補充療法; オリゴ糖; 亜鉛欠乏性味覚障害; 亜鉛吸収障害; 亜鉛; 血清ACE活性比; 血清亜鉛値

We developed the ratio of apo/ holo activities of angiotensin coverting enzyme(ACR ratio) in the serum and examined patients with taste impairment and healthy subjects for their zinc nutrition using ACE ration as an index. In addition to a significant increase in ACE ratio in taste impairment patients with low concentrations of zinc in serum, ACE ratio was also significant elevated in taste impairment patients with normal value of zinc. These finding indicate that zinc deficiency is a predominant factor underlying taste impairment even when zinc concentrations are within normal ranges in serum. But, there were no differences in dietary zinc intake between patients and age-adjusted healthy subjects, suggesting that patients with taste impairment have malabsorption of dietary zinc in the gastrointestinal tract. We then examined the effects of zinc supplementation with difructose that enhances the absorption of zinc on taste impairment and showed its favorable efficacy. It is suggested that zinc supplementation with difructose will be a new treatment in patients woth refractory taste impairment.

建立了血清血管紧张素转换酶apo/holo活性比值(ACR)，并以血管紧张素转换酶(ACE)日粮为指标，对味觉障碍患者和健康体检者的锌营养进行了检测。除血清锌浓度低的味觉障碍患者ACE比率显著升高外，锌浓度正常的味觉障碍患者的ACE比率也显著升高。这些发现表明，缺锌是导致味觉障碍的主要因素，即使血清锌浓度在正常范围内。但是，患者的膳食锌摄入量与年龄调整后的健康受试者无差异，提示味觉障碍患者存在胃肠道对膳食锌的吸收不良。然后，我们研究了添加二果糖的补锌对味觉障碍的促进锌吸收的效果，并显示了其良好的效果。提示补锌加二果糖治疗难治性味觉障碍是一种新的治疗方法。

项目成果

Effects of dietary zinc deprivation on zinc concentration and ratio of apo/holo-activities of angiotenesin converting enzyme in serum of mice

膳食缺锌对小鼠血清中锌浓度和血管紧张素转换酶apo/holo活性比值的影响

• 发表时间: 2011
• 期刊: Auris Nasus Larynx
• 影响因子: 1.7
• 作者: N.Sarukura;et al
• 通讯作者: et al

栄養素センサー研究の新展開:長寿健康社会のための栄養薬学:味覚受容と味覚障害

营养传感器研究新进展：长寿健康社会的营养药理学：味觉感知和味觉障碍

• 发表时间: 2011
• 作者: Masuda M;Wakasaki T;Suzui M;Ton S;Joe AK;Weinstein IB;武田憲昭
• 通讯作者: 武田憲昭

亜鉛酵素・トランスポーター研究の最前線:亜鉛酵素「アンギオテンシン変換酵素」活性比と味覚障害患者の亜鉛栄養状態の評価

锌酶/转运蛋白研究前沿：锌酶“血管紧张素转换酶”活性比及味觉障碍患者锌营养状况评估

• 发表时间: 2009
• 作者: Shiga;H.etal .;武田憲昭
• 通讯作者: 武田憲昭

Effects of zinc supplementation on serum zinc concentration and ratio of apo/ holo-activities of angiotensin converting enzyme in patients with taste impairment

补锌对味觉障碍患者血清锌浓度及血管紧张素转换酶apo/holo活性比值的影响

• DOI: 10.1016/j.anl.2009.07.003
• 发表时间: 2010
• 期刊: Auris Nasus Larynx
• 影响因子: 1.7
• 作者: T. Takaoka;N. Sarukura;C. Ueda;Y. Kitamura;B. Kalubi;N. Toda;K. Abe;S. Yamamoto and N. Takeda
• 通讯作者: S. Yamamoto and N. Takeda

Effects of dietary zinc deprivation on zinc concentration and ratio of apo/ holo-activities of angiotensin converting enzyme in serum of mice

膳食缺锌对小鼠血清锌浓度及血管紧张素转换酶apo/holo活性比值的影响

• 发表时间: 2011
• 期刊: Auris Nasus Larynx
• 影响因子: 1.7
• 作者: N. Sarukura;S. Takai;S. Ikemoto;T. Korin;Y. Ueda;Y. Kitamura;B. Kalubi;S. Yamamoto and N. Takeda
• 通讯作者: S. Yamamoto and N. Takeda