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Combined effect of sawa-wasabi and green tea to H. pylori and the related epidemiological study

泽芥末与绿茶联合对H. pylori的影响及相关流行病学研究

基本信息

批准号：
18500625
负责人：
KINAE Naohide
金额：
$ 2.13万
依托单位：
University of Shizuoka
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18500625/
关键词：
Wasabi green tea H. pylori bactericidal Mongolian gerbils epidemiological stud Stomach cancer

项目摘要

In previously, we reported several functional properties containing antibacterial potency of Sawa-wasabi (Wasabia japonica), a traditional spice and a special product of our prefecture. We also studied on antioxidative and antimutagenic effects of green tea (Camelia sinenses) a traditional beverage of Japan.In this paper, our purpose was to elucidate the combined preventive effect of wasabi and green tea to Helicobacter pylori induced stomach cancer. The epidemiological data between incidence of stomach cancer and intake of wasabi and/or green tea was required in this experiments.We obtained this following results from this study.(1) The ether extracts and water soluble fraction of wasabi leaves showed strong antioxdative activity.(2) The rhizomes and leaves of wasabi showed growth inhibition and disinfection to H.pylori.(3) Wasabi leaf extract showed strong radical scavenging activity.(4) The mixture of wasabi and green tea extracts exhibited bactericidal effect to H.pylori. additively.(5) By oral administration of wasabi leaf extract to H.pylori. injected Mongolian gerbils, the number of bacteria, injury and petechial hemorrhange scores of gastric mucosa was significantly decreased.(6) By epidemiological studies, the producing areas of wasabi and green tea stomach cancer SMR was lower than those of control areas. These experimental data demonstrates that the combined preventive effect between wasabi and green tea to H.pylori. infection might be expected.

在以前，我们报道了几个功能特性，包括抗菌效力的Sawa-Wasabi（山葵），一个传统的香料和我县的特产。本研究还对日本传统饮料绿色茶（Camelia sinenses）的抗氧化和抗突变作用进行了研究，旨在阐明山葵和绿色茶对幽门螺杆菌（Helicobacter pylori）诱发的胃癌的联合预防作用。本研究需要胃癌发病率与芥末和/或绿色茶摄入量之间的流行病学资料。(1)山葵叶的乙醚提取物和水溶性部分具有较强的抗氧化活性。(2)山葵的根茎和叶片对幽门螺杆菌有生长抑制和杀菌作用。(3)山葵叶提取物具有较强的自由基清除活性。(4)山葵和绿色茶提取物的混合物对幽门螺杆菌具有杀菌作用。相加(5)通过口服山葵叶提取物对幽门螺杆菌。注射后的沙土鼠胃粘膜细菌数、损伤程度及瘀点评分均明显降低。(6)通过流行病学调查，山葵和绿色茶产区胃癌SMR低于对照区。这些实验数据表明山葵和绿色茶对幽门螺杆菌的联合预防效果。感染是可以预料的。