Establishing cynomolgus monkey transplant models using tailor-made ES cells

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For the tailor-made ES cell establishment method using the somatic cell nuclear transfer method in the cynomlgus monkey, in addition to problem of embryo loss, the efficiency for creating blastocyst-stage embryos was extremely poor, and we reached the determination that regrettably ES cell establishment was extremely difficult. On the other hand, it was relatively easy to establish cynomolgus monkey iPS cells, and it goes without saying that iPS cells are expected to be useful in clinical application research.