Pathological and molecular biological analysis of nervous lesions caused by glioma-inducing retroviruses

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In order to clarify the pathogenesis of nervous system disorders due to retrovirus infection, fowl glioma-inducing virus (FGV) belonging to avian leukosis viruses (ALVs), FGV-mutants, and another ALVs isolated from chickens affected with glioma or peripheral nerve tumors were examined by molecular biological analysis and their pathogenicity to nervous system was compared by experimental infections. The main results suggest that env gene may be not a major determinant for the induction of glioma. Also, one transgenic (Tg) chimera chicken (G(0)) carrying FGV-LTR obtained in this study is expected to be useful for analysis of the LTR function.