Development of multi-functional denture liner

为了研制无酒精的多功能义齿衬里，制备了由脂肪族乙烯基酯(VE)液体和聚甲基丙烯酸乙酯(PEMA)粉末组成的新型义齿衬里。对于VE，从气味的角度出发，选择了高相对分子质量和室温下的液体--癸二酸二乙烯酯(DVS)和癸二酸甲酯(MVS)。通过与4种商用组织调节剂在粘弹性性能方面的比较，评价了新型DLS作为组织调节剂(TC)作为组织调节剂(TC)的可能性；与典型商品DLS相比，评价了聚合新型DLS作为长期组织调节剂的可能性。在混合后2小时，DVS/PEMA和MVS/PEMA糊料的初始应力松弛行为与典型的商品TCS相当。VE/PEMA糊料的初始硬度也与商品TC相当。然而，VE/PEMA在DIST中浸泡后硬度下降。在37℃下放置2周，水的变化仅为-14%，而商用TCS的硬度随着储存的增加而增加85%~269%。热聚合VE/PEMA糊的弯曲性能与市售DLS的弯曲性能相似，范围为28~58 Mpa。由AVE和PEMA组成的新型DLS被成功地用作TC和长期硬DL，展示了这些新材料的多用途用途。对DVS和MVS进行类雌激素活性、细胞毒性和皮肤致敏试验。所有测试的乙烯基酯都没有表现出任何雌激素活性。VE的IC50值(抑制活性50%所需的化学浓度)大于20 mM。DVS和MVS具有一定的皮肤致敏潜力，但被认为仅具有较弱的皮肤致敏效力。

To develop a multi-functional denture liner (DL) without an alcohol, the novel DLs composed of aliphatic vinyl ester (VE) liquid and poly(ethyl methacrylate) (PEMA) powder were prepared. As for VE, Divinyl sebacate (DVS) and Methyl vinyl sebacate (MVS) were selected as a high molecular weight and liquid at room temperature on the viewpoint of odor. The possibilities on mechanical properties of novel DLs were evaluated the potential as a tissue conditioner (TC) in comparison with 4 kinds of commercial TC on viscoelastic properties, and the possibilities on mechanical properties of polymerized novel DLs were evaluated the potential as a long-term DL in comparison with typical commercial DLs on the flexural properties. The initial stress relaxation behavior of DVS/PEMA and MVS/PEMA pastes were equivalent those of typical commercial TCs at 2 hrs after mixing. The initial hardness of VE/PEMA pastes were also equivalent those of commercial TC. However, the hardness of VE/PEMA pastes after immersion in dist. water at 37℃ for 2 weeks was changed only by -14% with that at the initial, while the hardness of commercial TCs increased by 85-269% with storage. The flexural properties of thermo-polymerized VE/PEMA pastes were similar to those of commercial DLs in the range of 28 to 58MPa. The novel DLs, composed of AVE and PEMA, were successfully used as both a TC and long-term hard DL, demonstrating the multiple purpose utility of these novel materials. The feasibility of DVS and MVS for DL were examined for estrogenic activity, cytotoxicity and skin sensitization potency. None of the vinyl esters tested exhibited any estrogenic activity. The IC50 values (the chemical concentration required to inhibit viability by 50%) of VE were more than 20mM. DVS and MVS have some potential to cause skin sensitization but was regarded as having only weak skin sensitizing potency.