The development of the quality evaluation system of gene-modified dendritic cells for cancer immunotherapy and gene therapy

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Virus-mediated delivery of therapeutic genes into dendritic cells(DCs) is a promising method for cancer immunotherapy. As there is not the public standard that determined the quality of the gene-modified DCs as the clinical experimental drug, it is the present conditions that the quality of gene-modified DCs is left to the judgment of each the enforcement organization. To develop the quality evaluation system of the gene-modified dendritic cells which are the final product, we clarified quality and stability of a vector/cells which are correspond to raw materials, then examined a method of gene transfer into dendritic cells.