The mechanism of atherosclerotic plaque disruption in apoE-deficient mice. The concept of the involvement of inflammation
The mechanism of atherosclerotic plaque disruption in apoE-deficient mice. The concept of the involvement of inflammation
批准号:
19700366
负责人:
SASAKI Takeshi
金额:
$2.34万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
心筋梗塞や脳梗塞は、血管の肥厚内膜が破れるプラーク破綻(破裂)が引き金になるとされているが、このプラーク破綻のメカニズムは不明のままである。研究代表者の佐々木は、マウスを用いたプラーク破綻モデルを作成し、そのメカニズムの解明を試みた。その結果、このマウスモデルにおけるプラーク破綻には、病変部に集積する炎症細胞(マクロファージ、好中球等)と、それらの細胞が放出するプロテアーゼが重要であることを明らかにした。
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Superoxide-dependent cathepsin activation is associated with hypertensive myocardial remodeling and represents a target for angiotensin II type I receptor blocker treatment.
超氧化物依赖性组织蛋白酶激活与高血压心肌重塑相关,是血管紧张素 II I 型受体阻滞剂治疗的靶点。
DOI:
--
发表时间:
2008
期刊:
Am J Pathol 173
影响因子:
--
作者:
[Cheng XW, Murohara T, Kuzuya M, Izawa H, Sasaki T, Obata K, Nagata K, Nishizawa T, Kobayashi M, Yamada T, Kim W, Sato K, Shi GP, Okumura K, Yokota M.]
通讯作者:
Yokota M.
実験動物を用いた疾患モデル作成術 (1)閉塞性血栓形成モデル
实验动物疾病模型制作(1)闭塞性血栓形成模型
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Takada, T., Mita, A., Maeno, A., Moriwaki, K., Yonekawa, H., Shiroishi, T., 佐々木健]
通讯作者:
佐々木健
DOI:
10.2353/ajpath.2008.071126
发表时间:
2008-08-01
期刊:
AMERICAN JOURNAL OF PATHOLOGY
影响因子:
6
作者:
[Cheng, Xian Wu, Murohara, Toyoaki, Yokota, Mitsuhiro]
通讯作者:
Yokota, Mitsuhiro
Plaque rupture model in mice
小鼠斑块破裂模型
DOI:
--
发表时间:
2007
期刊:
Methods in Molecular Medicine 139
影响因子:
--
作者:
[志村三代子, 御園生涼子, 他編著, 御園生 涼子(共著), Naoki Maeda, Naoki Maeda, Naoki Maeda, 前田尚輝, 前田尚輝, Nakamura K, Cheng XW, Ai S, Sasaki T]
通讯作者:
Sasaki T
研究会賞 第3回名古屋メタボリックシンドローム研究会 研究奨励賞
研究小组奖 第3届名古屋代谢综合症研究小组研究鼓励奖
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
共 34 条
Bequest and Security in Roman Law
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批准号:16K16974
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$1.66万
-
财政年份:2016
-
负责人:SASAKI Takeshi
-
依托单位:
Principals of Respect for Intentions of Children and Counsel for Children: A Comparative Research in Japan, Germany, and Austria
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批准号:25780072
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$1.41万
-
财政年份:2013
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负责人:SASAKI Takeshi
-
依托单位:
Mechanisms of abdominal aortic aneurysm formation.
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批准号:23591861
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
-
财政年份:2011
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负责人:SASAKI Takeshi
-
依托单位:
Characteristics of postural control disturbances in rats with or without brain lesion
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批准号:23650330
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.58万
-
财政年份:2011
-
负责人:SASAKI Takeshi
-
依托单位:
Geometry of affine spheres and projectivelyminimal surfaces
-
批准号:22540083
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.0万
-
财政年份:2010
-
负责人:SASAKI Takeshi
-
依托单位:
Transition Towards 21stCentury Governing System?: A Comparative Study of Major Democracies on the Political Decision Structure
-
批准号:21243009
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$19.97万
-
财政年份:2009
-
负责人:SASAKI Takeshi
-
依托单位:
The mechanism of atherosclerotic plaque disruption in experimental animal model. The concept of the involvement of cathepsins.
-
批准号:21700447
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.75万
-
财政年份:2009
-
负责人:SASAKI Takeshi
-
依托单位:
A study of systems of differential equations associated with projectively minimal surfaces
-
批准号:19540080
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.75万
-
财政年份:2007
-
负责人:SASAKI Takeshi
-
依托单位:
Study of transformations of Lie-minimal surfaces
-
批准号:17540076
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.98万
-
财政年份:2005
-
负责人:SASAKI Takeshi
-
依托单位:
Mechanism for human parvovirus B19-induced rheumatoid arthjritis
-
批准号:16390284
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.15万
-
财政年份:2004
-
负责人:SASAKI Takeshi
-
依托单位:
A Study of Secondary Education Reform in the United Kingdom : Comprehensive Schools and Diversification Policies
-
批准号:15330180
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$3.9万
-
财政年份:2003
-
负责人:SASAKI Takeshi
-
依托单位:
Etiological agents responsible for systemic lupus erythrmatosus
-
批准号:13470106
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.02万
-
财政年份:2001
-
负责人:SASAKI Takeshi
-
依托单位:
Antinucleic aid antibody gene therapy for rheumatoid Arthritis and adult T cell Leukemia
-
批准号:12557044
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.38万
-
财政年份:2000
-
负责人:SASAKI Takeshi
-
依托单位:
Construction of submanifolds via integrable systems
-
批准号:12304005
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$18.37万
-
财政年份:2000
-
负责人:SASAKI Takeshi
-
依托单位:
National Research and Study on Political Funding
-
批准号:10420013
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$7.49万
-
财政年份:1998
-
负责人:SASAKI Takeshi
-
依托单位:
Approarch for the viral agent responsible for rheumatoid arthritis
-
批准号:10307012
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$20.8万
-
财政年份:1998
-
负责人:SASAKI Takeshi
-
依托单位:
Studies in the relations between primary and secondary schooling and educational activities and facilities beyond schools in the United Kingdom
-
批准号:09610303
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.73万
-
财政年份:1997
-
负责人:SASAKI Takeshi
-
依托单位:
Research for human parvovirus and rheumatoid arthritis.
-
批准号:08457151
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$4.99万
-
财政年份:1996
-
负责人:SASAKI Takeshi
-
依托单位:
The Change of the Policy System in Japanese Politics since 1980s
-
批准号:06451098
-
项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$2.18万
-
财政年份:1994
-
负责人:SASAKI Takeshi
-
依托单位:
The role of human parvovirus infection in rheumatoid arthritis
-
批准号:04454232
-
项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$4.22万
-
财政年份:1992
-
负责人:SASAKI Takeshi
-
依托单位:
海外基金