Regulation of cell behavior through the interplays of cadherin cell adhesion molecules and cytoskeleton

通过钙粘蛋白细胞粘附分子和细胞骨架的相互作用调节细胞行为

• 批准号: 20002009
• 负责人: TAKEICHI Masatoshi
• 金额: $ 253.09万
• 依托单位: The Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Specially Promoted Research
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20002009/
• 关键词: カドヘリン; カテニン; アクチン; 微小管; 細胞接着; KIFC3; USP47; プロトカドヘリン; 神経軸索; 扁桃体; WAVE 複合体; 神経管; adherens junction; Celsr1; Rho kinase; Nezha; CAMSAP2; ゴルジ体; Fat; Dachsous; Willin; ゴルジ; Rock; 中心体; ネザ; エプリン; 細胞結合

We investigated the mechanisms of the cooperation between cadherin superfamily members and cytoskeletal proteins. The findings include 1) EPLIN is involved in the epithelial to mesenchymal transition of junctional architecture, 2) Fat4 and Dachsous1 are required for apical domain formation in neuroepithelial cells, 3) Willin regulates junctional constriction, 4) Celr1 is required for PCP formation of the neural plate, 5) protocadherin17 regulates collective axon extension. Furthermore, we identified Nezha/CAMSAP3 as a microtubule minus-end anchoring protein, and thereby advanced the research fields of non-centrosomal microtubules.

我们研究了钙粘蛋白超家族成员与细胞骨架蛋白之间的相互作用机制。这些发现包括：1)Eplin参与了连接结构从上皮到间充质的转变，2)Fat4和Dachsous1是神经上皮细胞顶区形成所必需的，3)Wlin调节连接收缩，4)Celr1是神经板PCP形成所必需的，5)Protocadherin 17调节集体轴突的伸展。此外，我们还鉴定了哪吒/CAMSAP3为微管负端锚定蛋白，从而推进了非中心体微管的研究领域。

项目成果

Dendrites of cerebellar granule cells correctly recognize their target axons for synaptogenesis in vitro

• DOI: 10.1073/pnas.0906653106
• 发表时间: 2009-08-04
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Ito, Shoko;Takeichi, Masatoshi
• 通讯作者: Takeichi, Masatoshi

Structural and functional diversity of cadherin at the adherens junction

粘附连接处钙粘蛋白的结构和功能多样性

• 发表时间: 2011
• 期刊: J. Cell Biol
• 作者: Oda;H.;and Takeichi;M
• 通讯作者: M

Planar cell polarity signals induce anisotropic contraction of neuroepithelial junctions leading to neural tube closure

平面细胞极性信号诱导神经上皮连接的各向异性收缩，导致神经管闭合

• 发表时间: 2012
• 作者: J.-S. Jung;T. Kimura et al.;竹市 雅俊
• 通讯作者: 竹市 雅俊

Shroom3-mediated recruitment of Rho kinases to the apical cell junctions regulates epithelial and neuroepithelial planar remodeling

• DOI: 10.1242/dev.019646
• 发表时间: 2008-04-15
• 期刊: DEVELOPMENT
• 影响因子: 4.6
• 作者: Nishimura, Tamako;Takeichi, Masatoshi
• 通讯作者: Takeichi, Masatoshi

Botulinum hemagglutinin disrupts the intercellular epithelial barrier by directly binding E-cadherin

• DOI: 10.1083/jcb.200910119
• 发表时间: 2010-05-17
• 期刊: JOURNAL OF CELL BIOLOGY
• 影响因子: 7.8
• 作者: Sugawara, Yo;Matsumura, Takuhiro;Fujinaga, Yukako
• 通讯作者: Fujinaga, Yukako