Regulation of cell behavior through the interplays of cadherin cell adhesion molecules and cytoskeleton

通过钙粘蛋白细胞粘附分子和细胞骨架的相互作用调节细胞行为

• 批准号: 20002009
• 负责人: TAKEICHI Masatoshi
• 金额: $ 253.09万
• 依托单位: The Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Specially Promoted Research
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20002009/
• 关键词: カドヘリン; カテニン; アクチン; 微小管; 細胞接着; KIFC3; USP47; プロトカドヘリン; 神経軸索; 扁桃体; WAVE 複合体; 神経管; adherens junction; Celsr1; Rho kinase; Nezha; CAMSAP2; ゴルジ体; Fat; Dachsous; Willin; ゴルジ; Rock; 中心体; ネザ; エプリン; 細胞結合

We investigated the mechanisms of the cooperation between cadherin superfamily members and cytoskeletal proteins. The findings include 1) EPLIN is involved in the epithelial to mesenchymal transition of junctional architecture, 2) Fat4 and Dachsous1 are required for apical domain formation in neuroepithelial cells, 3) Willin regulates junctional constriction, 4) Celr1 is required for PCP formation of the neural plate, 5) protocadherin17 regulates collective axon extension. Furthermore, we identified Nezha/CAMSAP3 as a microtubule minus-end anchoring protein, and thereby advanced the research fields of non-centrosomal microtubules.

我们研究了钙粘蛋白超家族成员与细胞骨架蛋白之间合作的机制。研究结果包括1）eplin参与连接体结构的间质转变，2）fat4和dachsous1是神经上皮细胞中顶端结构域形成所必需的，3）Willin调节连接约束，4）CELR1是Neural sprentive contresive contresive contresive contresive contresive contresive contrifite contrifite contrifite contrifite contrestive contrifite contrifite contrifite contrifite contristie contresties protocadhertrise protocadhershyry171717。此外，我们将Nezha/camsap3鉴定为微管负锚定蛋白，从而提高了非中心小管的研究领域。

项目成果

EPLIN mediates linkage of the cadherin-catenin complex to F-actin and stabilizes the circumferential actin belt

• DOI: 10.1073/pnas.0710504105
• 发表时间: 2008-01-08
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Abe, Kentaro;Takeichi, Masatoshi
• 通讯作者: Takeichi, Masatoshi

Dendrites of cerebellar granule cells correctly recognize their target axons for synaptogenesis in vitro

• DOI: 10.1073/pnas.0906653106
• 发表时间: 2009-08-04
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Ito, Shoko;Takeichi, Masatoshi
• 通讯作者: Takeichi, Masatoshi

Morphogenesis through the regulation of adherens junction" (Plenary Lecture)

通过调节粘附连接实现形态发生”（全体演讲）

• 发表时间: 2009
• 作者: Takeichi;M
• 通讯作者: M

Adherens Junction: Molecular architecture and regulation. In "Cell-Cell Junctions, Cold Spring Harbor Perspectives in Biology, ed. W.J. Nelson & E. Fuchs,"

粘附连接：分子结构和调节。

• 发表时间: 2010
• 期刊: Cold Spring Harbor Laboratory Press
• 作者: Meng;W.;and Takeichi;M
• 通讯作者: M

Mammalian Fat and Dachsous cadherins regulate apical membrane organization in the embryonic cerebral cortex.

• DOI: 10.1083/jcb.200811030
• 发表时间: 2009-06-15
• 期刊: The Journal of cell biology
• 作者: Ishiuchi T;Misaki K;Yonemura S;Takeichi M;Tanoue T
• 通讯作者: Tanoue T