Regulation of cell behavior through the interplays of cadherin cell adhesion molecules and cytoskeleton

我们研究了钙粘蛋白超家族成员与细胞骨架蛋白之间的相互作用机制。这些发现包括：1)Eplin参与了连接结构从上皮到间充质的转变，2)Fat4和Dachsous1是神经上皮细胞顶区形成所必需的，3)Wlin调节连接收缩，4)Celr1是神经板PCP形成所必需的，5)Protocadherin 17调节集体轴突的伸展。此外，我们还鉴定了哪吒/CAMSAP3为微管负端锚定蛋白，从而推进了非中心体微管的研究领域。

We investigated the mechanisms of the cooperation between cadherin superfamily members and cytoskeletal proteins. The findings include 1) EPLIN is involved in the epithelial to mesenchymal transition of junctional architecture, 2) Fat4 and Dachsous1 are required for apical domain formation in neuroepithelial cells, 3) Willin regulates junctional constriction, 4) Celr1 is required for PCP formation of the neural plate, 5) protocadherin17 regulates collective axon extension. Furthermore, we identified Nezha/CAMSAP3 as a microtubule minus-end anchoring protein, and thereby advanced the research fields of non-centrosomal microtubules.