Development of Materials with Novel Properties and Functions Based on Controlled Double-Stranded Helical Structure

在这个项目中，我们开发了一种全新的、通用的方法来构建各种人工双链螺旋聚合物和低聚物，这些聚合物和低聚物具有特定的功能，包括手性识别、不对称催化和自我复制。我们成功地合成了一系列螺旋度可控的互补双链螺旋聚合物和低聚物，通过螺旋手性的扩增，显示出独特的类似DNA的完美序列和分子长度识别和复制。螺旋结构的测定也是通过对聚合物的直接显微镜观察来实现的。我们还发现了一种耐人寻味的双螺旋分子，它在外部刺激的触发下表现出可逆的弹簧式伸缩运动。我们开发了实用的手性材料，用于拆分对映体和制备单一对映体作为不对称催化剂。

In this project, we have developed a conceptually new and versatile method for constructing a variety of artificial double-stranded helical polymers and oligomers with specific functions involving chiral recognition, asymmetric catalysis, and self-replication. We have successfully synthesized a series of complementary double-stranded helical polymers and oligomers with a controlled helicity that showed unique DNA-like perfect sequence and molecular length recognition and replication via amplification of the helical chirality. The determination of the helical structures is also achieved by direct microscopic observations of the polymers. We also discovered an intriguing double helical molecule that exhibited a reversible spring-like extension-contraction motion triggered by external stimuli. We developed practically useful chiral materials for separating enantiomers and producing single enantiomers as asymmetric catalysts.