Development of Materials with Novel Properties and Functions Based on Controlled Double-Stranded Helical Structure

在这个项目中，我们开发了一种概念上新的和通用的方法，用于构建各种人工双链螺旋聚合物和寡聚物，具有特定的功能，包括手性识别，不对称催化和自我复制。我们已经成功地合成了一系列互补的双链螺旋聚合物和低聚物，具有可控的螺旋度，显示出独特的DNA样的完美序列和分子长度的识别和复制通过扩增的螺旋手性。螺旋结构的测定也通过聚合物的直接显微观察来实现。我们还发现了一种有趣的双螺旋分子，它表现出由外部刺激触发的可逆的弹簧样伸展-收缩运动。我们开发了具有实用价值的手性材料作为不对称催化剂，用于分离对映体和制备单一对映体。

In this project, we have developed a conceptually new and versatile method for constructing a variety of artificial double-stranded helical polymers and oligomers with specific functions involving chiral recognition, asymmetric catalysis, and self-replication. We have successfully synthesized a series of complementary double-stranded helical polymers and oligomers with a controlled helicity that showed unique DNA-like perfect sequence and molecular length recognition and replication via amplification of the helical chirality. The determination of the helical structures is also achieved by direct microscopic observations of the polymers. We also discovered an intriguing double helical molecule that exhibited a reversible spring-like extension-contraction motion triggered by external stimuli. We developed practically useful chiral materials for separating enantiomers and producing single enantiomers as asymmetric catalysts.