Epstein-Barr virus lytic replication and host factors supporting its replication
Epstein-Barr virus lytic replication and host factors supporting its replication
批准号:
20390137
负责人:
TSURUMI Tatsuya
金额:
$12.65万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Epstein-Barr virus (EBV) is a DNA tumor virus、possessing two alternative life cycle ; latent and lytic. EBV genome replication is occurred in nuclei of the infected cells. In this study we have revealed that TORC2 (Transducer of Regulated CREB 2) and HIF-2αis involved in the reactivation from the latency. Furthermore, We have showed the three dimensional structure of BMRF1, one of EBV replication proteins, and its relationship with its functions on DNA binding, polymerase processivity, and lytic replication.
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Tail to tail contact for tetrameric ring formation of EBV BMRF1 is crucial for viral replication
EBV BMRF1 四聚环形成的尾对尾接触对于病毒复制至关重要
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[中山早苗, 村田貴之, 鶴見達也]
通讯作者:
鶴見達也
The impact of viral repetitive sequences on the biological properties of Epstein-Barr virus recombinants1
病毒重复序列对 Epstein-Barr 病毒重组体生物学特性的影响1
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Kanda T., Tsurumi T.]
通讯作者:
Tsurumi T.
Human cytomegalovirus UL76 contains an internal ribosome entry site to facilitate UL77 translation
人巨细胞病毒 UL76 包含一个内部核糖体进入位点以促进 UL77 翻译
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[磯村寛樹, 鶴見達也]
通讯作者:
鶴見達也
DOI:
10.1074/jbc.m808466200
发表时间:
2009-03-20
期刊:
JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子:
4.8
作者:
[Murata, Takayuki, Sato, Yoshitaka, Tsurumi, Tatsuya]
通讯作者:
Tsurumi, Tatsuya
EBウイルス溶解感染時にp53はBZLF1-ECSユビキチンリガーゼによって分解される
p53 在 EB 病毒裂解感染过程中被 BZLF1-ECS 泛素连接酶降解
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[佐藤好隆, 鶴見達也]
通讯作者:
鶴見達也
共 47 条
Architecture and Function of the Epstein-Barr virus Replication Compartment
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批准号:24659213
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
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财政年份:2012
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负责人:TSURUMI Tatsuya
-
依托单位:
Molecular basis for Epstein-Barr virus replication
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批准号:23390118
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.65万
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财政年份:2011
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负责人:TSURUMI Tatsuya
-
依托单位:
Host Cellular responses accompanied by Epstein-Barr Virus genome replication.
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批准号:18390147
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.69万
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财政年份:2006
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负责人:TSURUMI Tatsuya
-
依托单位:
Latent and lytic replication of Epstein-Barr virus.
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批准号:16017322
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$9.6万
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财政年份:2004
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负责人:TSURUMI Tatsuya
-
依托单位:
Host cellular functions supporting Epstein-Barr virus genome replication.
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批准号:15390153
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.15万
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财政年份:2003
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负责人:TSURUMI Tatsuya
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依托单位:
Molecular Mechanism of Epstein-Barr virus DNA replication in viral infected tumors and cellular immunity for viral associated cancers
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批准号:11138268
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas (A)
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资助金额:$3.2万
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财政年份:1999
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负责人:TSURUMI Tatsuya
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依托单位:
Functional Analyses of Epstein-Barr virus DNA replication machinery consisting of viral elongation factors
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批准号:09670310
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:1997
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负责人:TSURUMI Tatsuya
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依托单位:
海外基金