Molecular basis for Epstein-Barr virus replication

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Epstein-Barr virus possesses two alternative life cycles, latent and lytic.In the latent phase, reactivation of BZLF1 promoter is inhibited. We determined that histons around the promoter region we re negatively methylated and positive histon markers were increased after induction of lytic replication. JDP2 transcription factor contributed the establishment of the latent infection. In the lytic phase, viral replication occurs in replication compartments(RC). BMRF-1 core exists within RC. Viral DNA packaging proteins were found in the core and viral immediate-eartly and early transcription occurs outside the core, while late transcription was inside. Thus, each events were compartmentalized by the BMRF-1 core.