Development of cell, gene and drug delivery system to the cardiovascular tissue using a novel cell-surface lectin.

使用新型细胞表面凝集素开发心血管组织的细胞、基因和药物输送系统。

• 批准号: 20390222
• 负责人: IKEDA Uichi
• 金额: $ 11.9万
• 依托单位: Shinshu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390222/
• 关键词: 再生医療; 糖鎖; 遺伝子; 心筋梗塞; 動脈硬化; 心筋細胞

We found a novel function of vimentin and desmin of cardiovascular tissues by which these proteins interact with physiological GlcNAc-bearing ligands on the cell surface through their GlcNAc-binding lectin-like properties. Cell surface coating of bone marrow cells with GlcNAc promoted adhesion of these cells to cardiac myocytes and their regeneration to cardiac myocytes, and this would be useful for the treatment of cardiovascular disease with bone marrow implantation.

我们发现了心血管组织的波形蛋白和结蛋白的新功能，通过这些蛋白质与细胞表面上的生理GlcNAc承载配体通过其GlcNAc结合凝集素样性质相互作用。用GlcNAc包被骨髓细胞表面可促进这些细胞与心肌细胞的粘附及其向心肌细胞的再生，这将有助于骨髓移植治疗心血管疾病。

项目成果

Development of the Targeting for Myocardium by Artificial Glycoside-coated Bone Marrow Cells. (人工的な糖鎖修飾を行った骨髄細胞の心筋組織へのターゲティング法の開発)

人工糖苷包被的骨髓细胞靶向心肌的发展。

• 发表时间: 2008
• 作者: Satoshi Kobayashil;Hirohiko Ise;Masafumi Takahashil;Mitsuaki Goto;Shinichi Aso;Uichi Ikeda
• 通讯作者: Uichi Ikeda

Changes in angiogenesis-related factors in serum following autologous bone marrow cell implantation for severe limb ischemia

• DOI: 10.1517/14712598.8.6.705
• 发表时间: 2008-05
• 期刊: Expert Opinion on Biological Therapy
• 影响因子: 4.6
• 作者: Yoshihito Tachi;D. Fukui;Y. Wada;Megumi Koshikawa;S. Shimodaira;Uichi Ikeda;J. Amano

糖鎖工学を利用した骨髄幹細胞の心臓ターゲッティング法の開発

利用糖工程开发骨髓干细胞心脏靶向方法

• 发表时间: 2008
• 作者: 小林聡;伊勢裕彦;高橋将文;後藤光昭;麻生真一;池田宇一
• 通讯作者: 池田宇一

Noninvasive evaluation of coronary endothelial function following sirolimus-eluting stent implantation by using positron emission tomography

正电子发射断层扫描无创评估西罗莫司洗脱支架植入后冠状动脉内皮功能

• 发表时间: 2009
• 期刊: Cradiolongy 114
• 作者: Horigome M;Kumazaki S;Hattori N;Kasai H;Horigome M;Aizawa K;Izawa A;Tomita T;Tsutsui H;Koyama J;Sakurai S;Ikeda U
• 通讯作者: Ikeda U

Systemic delivery of IL-10 by an AAV vector prevents vascular remodeling and end-organ damage in stroke-prone spontaneously hypertensive rat

• DOI: 10.1038/gt.2008.151
• 发表时间: 2009-03-01
• 期刊: GENE THERAPY
• 影响因子: 5.1
• 作者: Nomoto, T.;Okada, T.;Ozawa, K.
• 通讯作者: Ozawa, K.