Development of cell, gene and drug delivery system to the cardiovascular tissue using a novel cell-surface lectin.

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We found a novel function of vimentin and desmin of cardiovascular tissues by which these proteins interact with physiological GlcNAc-bearing ligands on the cell surface through their GlcNAc-binding lectin-like properties. Cell surface coating of bone marrow cells with GlcNAc promoted adhesion of these cells to cardiac myocytes and their regeneration to cardiac myocytes, and this would be useful for the treatment of cardiovascular disease with bone marrow implantation.