Translational research of developing liver regeneration and antie agent derived from platelets

开发肝再生和血小板源抗剂的转化研究

• 批准号: 20390350
• 负责人: OHKOHCHI Nobuhiro
• 金额: $ 12.73万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390350/
• 关键词: 肝臓外科学; 肝再生; 肝臓; 血小板; 肝線維化; 治療法

The aim of this research is to develop new reagent for liver regeneration and anti-fibrosis. We clarified that human platelets directly deactivate human stellate cell by ATP and adenosine derived from human platelets. We also clarified that S1P from human platelets activate human liver sinusoidal endothelial cells to secrete IL-6 and proliferate hepatocytes. From these results, we will develop new reagents for treating severe liver diseases.

本研究的目的是开发新的肝再生和抗纤维化试剂。我们阐明了人血小板通过来自人血小板的ATP和腺苷直接使人星状细胞失活。我们还阐明，从人血小板S1 P激活人肝窦内皮细胞分泌IL-6和增殖肝细胞。根据这些结果，我们将开发治疗严重肝病的新试剂。

项目成果

3種類の肝切除モデルを用いた血小板による肝再生促進効果の検討

利用三种肝切除模型检查血小板促进肝再生的作用

• 发表时间: 2010
• 作者: 村田聡一郎;Andriy Myronovych;中野順隆;大河内信弘
• 通讯作者: 大河内信弘

New therapy for promotion of regeneration and resolution of fibrosis in the liver by platelets : basic research to clinical trial

血小板促进肝脏再生和纤维化消退的新疗法：基础研究到临床试验

• 发表时间: 2009
• 作者: 村田聡一郎;大河内信弘;渡辺基信;中野順隆;A Myronovych;福永潔
• 通讯作者: 福永潔

Platelet Administration Via the Portal Vein Promotes Liver Regeneration in Rats After 70% Hepatectomy

• DOI: 10.1097/sla.0b013e318211caf8
• 发表时间: 2011-04-01
• 期刊: ANNALS OF SURGERY
• 影响因子: 9
• 作者: Matsuo, Ryota;Nakano, Yoritaka;Ohkohchi, Nobuhiro
• 通讯作者: Ohkohchi, Nobuhiro

Single Administration of Thrombopoietin Prevents Progression of Liver Fibrosis and Promotes Liver Regeneration After Partial Hepatectomy in Cirrhotic Rats

• DOI: 10.1097/sla.0b013e31818584c7
• 发表时间: 2008-11-01
• 期刊: ANNALS OF SURGERY
• 影响因子: 9
• 作者: Murata, Soichiro;Hashimoto, Ikuka;Hkohchi, Nobuhiro
• 通讯作者: Hkohchi, Nobuhiro

Existence of Pink1 Antisense RNAs in Mouse and Their Localization

• DOI: 10.1159/000251963
• 发表时间: 2009-01-01
• 期刊: CYTOGENETIC AND GENOME RESEARCH
• 影响因子: 1.7
• 作者: Chiba, M.;Kiyosawa, H.;Yasue, H.
• 通讯作者: Yasue, H.