Mechanism for maintenance of homeostasis of several functions by connexin 43

连接蛋白 43 维持多种功能稳态的机制

• 批准号: 20390470
• 负责人: MORITA Ikuo
• 金额: $ 12.15万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390470/
• 关键词: コネキシン; ギャップ結合; 薬物導入法; annular gap; 細胞分化; リポソーム; DDS; ナノサイエンス; PI3キナーゼ; AKT; 細胞マニピュレーション

To clarify a role of connexin 43 (Cx43) in vivo, we produced the substrate in which only two cells are able to be adjacent, the mutated Cx43 proteins, and Cx43 integrated liposomes. By using these techniques, it is demonstrated that the amino-acid sequence between C325 and C342 in Cx43 protein and Caveolin-1 are involved in the incorporation of Cx43-plaques. These findings show a novel mechanism for cell-cell interaction and takes part in the maintenance of homeostasis in several functions.

为了阐明连接蛋白43（Cx43）在体内的作用，我们制备了其中仅两个细胞能够相邻的底物、突变的Cx43蛋白和Cx43整合的脂质体。通过这些技术，证明Cx43蛋白和Caveolin-1中C325和C342之间的氨基酸序列参与Cx43-斑块的掺入。这些发现显示了细胞间相互作用的一种新机制，并参与了几种功能的稳态维持。

项目成果

ギャップ結合の調節機序とDDSへの応用

间隙连接的调控机制及其在DDS中的应用

• 发表时间: 2009
• 作者: 住友倫子;中田匡宣;東野美晴;寺尾豊;川端重忠;森田育男
• 通讯作者: 森田育男

The reduction in pigment epithelium-derived factor is a sign of malignancy in ovarian cancer expressing low-level of vascular endothelial growth factor

• DOI: 10.1080/09513590802549841
• 发表时间: 2009-01
• 期刊: Gynecological Endocrinology
• 影响因子: 2
• 作者: T. Tsuchiya;K. Nakahama;Y. Asakawa;T. Maemura;Masanobu Tanaka;S. Takeda;M. Morita;I. Morita

Cell‐printing and transfer technology applications for bone defects in mice

• DOI: 10.1002/term.366
• 发表时间: 2011-10
• 期刊: Journal of Tissue Engineering and Regenerative Medicine
• 影响因子: 3.3
• 作者: Junichi Tsugawa;M. Komaki;Tomoko Yoshida;K. Nakahama;T. Amagasa;I. Morita

The role of Mac-1 (CD11b/CD18)in osteoclast differentiation induced by receptor activator of nuclear factor-kB ligand.

Mac-1 (CD11b/CD18)在核因子-kB配体受体激活剂诱导破骨细胞分化中的作用。

• 发表时间: 2008
• 期刊: FEBS Letters 582
• 作者: Hayashi H;Nakahama K;Sato T;Tuchiya T;Asakawa Y;MaemuraT;Tanaka M;Morita I
• 通讯作者: Morita I

Analysis of accelerated osteoclast formation by metabolica cidosis

代谢性酸中毒加速破骨细胞形成的分析

• 发表时间: 2008
• 作者: Kato K;Morita I.
• 通讯作者: Morita I.