Mechanism for maintenance of homeostasis of several functions by connexin 43

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To clarify a role of connexin 43 (Cx43) in vivo, we produced the substrate in which only two cells are able to be adjacent, the mutated Cx43 proteins, and Cx43 integrated liposomes. By using these techniques, it is demonstrated that the amino-acid sequence between C325 and C342 in Cx43 protein and Caveolin-1 are involved in the incorporation of Cx43-plaques. These findings show a novel mechanism for cell-cell interaction and takes part in the maintenance of homeostasis in several functions.