Regulation of human nasal mucosal barrier by tight junctions via innate immunity
Regulation of human nasal mucosal barrier by tight junctions via innate immunity
批准号:
20590346
负责人:
KOJIMA Takashi
金额:
$3.0万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
In the present study, we investigated the regulation of human nasal mucosal barrier by tight junctions in the nasal epithelial cells and dendritic cells to prevent and therapy for infections and allergy. TSLP (high-expression in allergic rhinitis), TLR3 (association with innate immunity), PPAR-gamma (nuclear hormone receptor) and RSV (infection in human airway) affected the barrier by tight junctions via distinct signal transduction pathways including PKC.
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Regulation of a hepatitis C virus co-receptor claudin-1 in hepatocytes
肝细胞中丙型肝炎病毒辅助受体claudin-1的调节
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Ohmori H, Kuniyasu H, et al., 小島隆]
通讯作者:
小島隆
DOI:
10.1111/j.1478-3231.2007.01631.x
发表时间:
2008-04-01
期刊:
LIVER INTERNATIONAL
影响因子:
6.7
作者:
[Kojima, Takashi, Takano, Ken-ichi, Sawada, Norimasa]
通讯作者:
Sawada, Norimasa
RS ウイルス感染症と喘鳴・喘息
RS病毒感染和喘息/哮喘
DOI:
10.11374/shonijibi.31.248
发表时间:
2010
期刊:
影响因子:
--
作者:
[裕幸 堤, 賢史 平川, 智之 正木, 徹夫 氷見, 環樹 岡林, 伸一 横田, 暢弘 藤井, 隆司 小島, 典均 澤田]
通讯作者:
典均 澤田
核内受容体PPAR-γを介したヒト鼻粘膜におけるタイト結合の発現調節機構
核受体PPAR-γ介导的人鼻粘膜紧密连接表达的调节
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[小笠原徳子, 小島隆, 郷充, 亀倉隆太, 大國毅, 正木智之, 村田雅樹, 田中敏, 千葉英樹, 氷見徹夫, 澤田典均]
通讯作者:
澤田典均
RSウィルス感染症と喘鳴・喘息
RSV 感染和喘息/哮喘
DOI:
--
发表时间:
2010
期刊:
小児耳鼻咽喉科 31(3)
影响因子:
--
作者:
[堤裕幸, 平川賢史, 正木智之, 氷見徹夫, 岡林環樹, 横田伸一, 藤井暢弘, 小島隆, 澤田典均]
通讯作者:
澤田典均
共 51 条
Development of Novel Synthetic Process for Porous Particles Using Alkoxide Method
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批准号:26420675
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.33万
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财政年份:2014
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负责人:KOJIMA Takashi
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依托单位:
The basic study of molecular targeted therapy via pancreatic duct tight junctions by using a novel culture system of human pancreatic duct epithelial cells
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批准号:23590404
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.33万
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财政年份:2011
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负责人:KOJIMA Takashi
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依托单位:
A study on the use of illegal drugs toxicity information to increase the effectiveness of drug abuse prevention education
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批准号:22500653
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.75万
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财政年份:2010
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负责人:KOJIMA Takashi
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依托单位:
Microstructure Control of Ceramic Composites by Self-Organization
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批准号:20760447
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.66万
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财政年份:2008
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负责人:KOJIMA Takashi
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依托单位:
Regulation of bile canalicular barrier by a novel tight junction protein claudin-2 during cholestasis
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批准号:17590308
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2005
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负责人:KOJIMA Takashi
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依托单位:
Financial Administration and Bank Accounting and Audit
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批准号:17530344
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.77万
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财政年份:2005
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负责人:KOJIMA Takashi
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依托单位:
The role of gap and tight junctions during liver regeneration
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批准号:13670224
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2001
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负责人:KOJIMA Takashi
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依托单位:
Financial Administration in Japan and the Audit by Certified Public Accountants
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批准号:13630165
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.6万
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财政年份:2001
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负责人:KOJIMA Takashi
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依托单位:
Analysis of experimental autoimmune myositis and its immunotherapy
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批准号:09670682
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.79万
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财政年份:1997
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负责人:KOJIMA Takashi
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依托单位:
Electron microscopic investigation of ribonucleic acid in nuclear particulate aggregates of hepatitis NANB by means of nuclease-gold complexes.
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批准号:62570315
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1987
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负责人:KOJIMA Takashi
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依托单位:
海外基金