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Physiological roles of signal transducers and modulators in the regulation of B cell functions.

Physiological roles of signal transducers and modulators in the regulation of B cell functions.
信号转导器和调节器在 B 细胞功能调节中的生理作用。
批准号:
20590492
负责人:
KOBAYASHI Takashi
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
Physiological roles of signal transducers and modulators in B cells were investigated. It has been clarified that TRAF6, a signal transducer of CD40 and Toll-like receptor family, is necessary for an appropriate humoral immune response and the development of a certain B cell subset. On the other hand, SOCS1, a suppressor of cytokine signaling, regulates the susceptibility to IgE-dependent allergic responses in vivo by suppressing IL-4/STAT6 pathway and subsequent IgE production in B cells.
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会议论文
アレルギー・免疫(感染症制御における制御性T細胞 vol.16(5))
过敏/免疫(传染病控制中的调节性T细胞第16(5)卷)
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [小林隆志, 川澄みゆり, 濱野真二郎]
通讯作者: 濱野真二郎
DOI: 10.1093/intimm/dxq472
发表时间: 2011-03
期刊: International immunology
影响因子: 4.4
作者: [M. Nakaya;S. Hamano;M. Kawasumi;H. Yoshida;A. Yoshimura;Takashi Kobayashi]
通讯作者: M. Nakaya;S. Hamano;M. Kawasumi;H. Yoshida;A. Yoshimura;Takashi Kobayashi
Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat
Foxp3 通过与 RORgammat 直接相互作用抑制 RORgammat 介导的 IL-17A mRNA 转录
DOI: --
发表时间: 2008
期刊: J Biological Chemistry 283
影响因子: --
作者: [Ichiyama K, Chinen, T, Kobayashi T, et.al.]
通讯作者: et.al.
Loss of SOCS1 in B cells results in hyper IgE syndrome (HIES) and predisposes to allergy in mice.
B 细胞中 SOCS1 的缺失会导致高 IgE 综合征 (HIES),并导致小鼠容易过敏。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Takashi Kobayashi, Yuko Matsunaga, Miyuri Kawasumi, Satoru Fukuyama, Hiromasa Inoue, Akihiko Yoshimura]
通讯作者: Akihiko Yoshimura
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