The Practical Use Study of Tailor made medicine : Accerelate of genotyping System and Feedback System to Primary Doctor

定制医疗的实际应用研究:加速基因分型系统和对基层医生的反馈系统

• 批准号: 20590549
• 负责人: KOBAYASHI Shinichi
• 金额: $ 3.08万
• 依托单位: St.Marianna University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590549/
• 关键词: テーラーメード医療; 抗癌薬; 遺伝子多型; 薬物代謝酵素; トランスポーター; DPD; ハプロタイプ

We were constructed the genotyping system which was efficiently measurement of genotype for CYP and transporter. The system which was able to analyze a lot of multi genotypes with accuracy in a short time was constructed for CYP2D6 and CYP3A4. During this experimental period, new sample was collected and done genotyping. Surgeon was request more simple information of the feedback system of multi genotype.

我们建立了一套能有效检测β-内酰胺酶和转运蛋白基因型的基因分型系统。建立了能在短时间内准确分析多种基因型的CYP 2D 6和CYP 3A 4的系统。在此实验期间，收集新样本并进行基因分型。外科医生对多基因型反馈系统的信息要求更简单。

项目成果

Comparative Study of Culture Conditions for Maintaining CYP3A4 and ATP-Binding Cassette Transporters Activity in Primary Cultured Human Hepatocytes.

原代培养人肝细胞中维持 CYP3A4 和 ATP 结合盒转运蛋白活性的培养条件的比较研究。

• 发表时间: 2011
• 期刊: Journal of Pharmacological Sciences. vol.115、No.4
• 作者: Yuko Takeba;Naoki Matsumoto;Sachiko Takenoshita-Nakaya;Yoshie Harimoto;Toshio Kumai;Yuichi Kinoshita;Hiroshi Nakano;Takehito Ohtsubo;Shinichi Kobayashi
• 通讯作者: Shinichi Kobayashi

Potential of lansoprazole as a novel probe for cytochrome P450 3A activity by measuring lansoprazole sulfone in human liver microsomes.

通过测量人肝微粒体中的兰索拉唑砜，研究兰索拉唑作为细胞色素 P450 3A 活性的新型探针的潜力。

• 发表时间: 2009
• 期刊: Biol Pharm Bull. vol.32、No.8
• 作者: Yanagida Y;Watanabe M;Takeba Y,Kumai T;Matsumoto N;Hayashi M;Suzuki S;Kinoshita Y;Kobayashi S
• 通讯作者: Kobayashi S

Comparative Study of Culture Conditions for Maintaining CYP3A4 and ATP-Binding Cassette Transporters Activity in Primary Cultured Human Hepatocytes

原代培养人肝细胞中维持 CYP3A4 和 ATP 结合盒转运蛋白活性的培养条件的比较研究

• 发表时间: 2011
• 期刊: Journal of Pharmacological Sciences
• 影响因子: 3.5
• 作者: Yuko Takeba;et. al
• 通讯作者: et. al