Applied Reserch of Apop protein for the treatment of Atherosclerosis

Apop蛋白治疗动脉粥样硬化的应用研究

• 批准号: 20590882
• 负责人: YASUDA Osamu
• 金额: $ 2.91万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590882/
• 关键词: 分子血管病態学; アポトーシス; 動脈硬化; ミトコンドリア; Apop

Apoptogenic Protein (Apop) was originally identified in the atherosclerotic plaques of model animals. Apop gene expression was also identified in human atherosclerosis in carotid arteries. Proliferative smooth muscle cells, which contribute to the formation of atherosclerosis, expressed Apop, while contractile smooth muscle cells in normal arteries did not. These findings indicate the implication of Apop in the development of atherosclerosis. Moreover, Apop deficient mouse was generated in this study to reveal the function of Apop gene in vivo.

致细胞凋亡蛋白(APOP)最初发现于模型动物的动脉粥样硬化斑块中。在人类颈动脉粥样硬化中也发现了APOP基因的表达。促进动脉粥样硬化形成的增殖性平滑肌细胞表达APOP，而正常动脉的收缩平滑肌细胞则不表达APOP。这些发现提示APOP在动脉粥样硬化的发生发展中的意义。此外，本研究还建立了APOP基因缺陷小鼠，以揭示APOP基因在体内的功能。

项目成果

Timp-3 deficiency impairs cognitive function in mice

• DOI: 10.1038/labinvest.2009.101
• 发表时间: 2009-12-01
• 期刊: LABORATORY INVESTIGATION
• 影响因子: 5
• 作者: Baba, Yoshichika;Yasuda, Osamu;Rakugi, Hiromi
• 通讯作者: Rakugi, Hiromi

Ezetimibe Ameliorates Cardiovascular Complications and Hepatic Steatosis in Obese and Type 2 Diabetic db/db Mice

• DOI: 10.1124/jpet.110.170373
• 发表时间: 2010-10-10
• 期刊: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
• 影响因子: 3.5
• 作者: Fukuda, Masaya;Nakamura, Taishi;Kim-Mitsuyama, Shokei
• 通讯作者: Kim-Mitsuyama, Shokei

血管内皮細胞における接着因子発現に対するKlotho蛋白の作用

Klotho蛋白对血管内皮细胞粘附因子表达的影响

• 发表时间: 2008
• 作者: 安田修;樂木宏実;安田 修;竹村幸宏;前川佳敬
• 通讯作者: 前川佳敬

Ad iponect in can decrease systemic inflammation through clearance of of apoplotic bodies

Ad iponect 可以通过清除质外体来减少全身炎症

• 发表时间: 2008
• 作者: Yasuda O;Fukuo K;Rakugi H.;Yasuda o;Takemura Y
• 通讯作者: Takemura Y

Nifedipine Inhibits Vascular Smooth Muscle Cell Dedifferentiation via Downregulation of Akt Signaling

• DOI: 10.1161/hypertensionaha.110.149781
• 发表时间: 2010-08-01
• 期刊: HYPERTENSION
• 影响因子: 8.3
• 作者: Kaimoto, Taeko;Yasuda, Osamu;Rakugi, Hiromi
• 通讯作者: Rakugi, Hiromi