The regulatory mechanism of claudins for paracellular pathway of the human amniotic epithelium.

羊膜上皮与羊水直接接触，并通过紧密连接通过细胞旁通路调节羊水通量。在本研究中，我们研究紧密连接和claudin的调控机制，作为早产和绒毛膜羊膜炎的基础研究。研究结果表明，激素、炎性细胞因子等多种生理活性物质可通过claudin调节羊膜紧密连接的通透性。

The amniotic epithelium is in direct contact with the amniotic fluid and regulates fluid flux via paracellular pathway by tight junctions. In this study, we investigated the regulatory mechanism of tight junctions and claudins as the basic research for premature birth and chorioamnionitis. The results have been shown that several physiological active substances such as hormone and inflammatory cytokines regulate the permeability of amniotic tight junctions through claudins.