Localization mechanism of a Ca^<2+> pump modulator, phospholamban in cardiac sarcoplasmic reticulum

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Phospholamban (PLN) is a regulator of the myocardiac contractility in cardiac sarcoplasmic reticulum (SR). Controling the subcellular localization of PLN leads to the prospect for new therapy of heart failure. In this study, it was suggested that the C-terminal region of PLN is critical for localization of PLN to SR. Based on this finding, the identification of a putative protein interacting to the C-terminal region of PLN was attempted. Furthermore, a novel PLN-targeted aptamer was successfully developed as the useful molecular tool for detection of the PLN-binding protein.