Regulation of stem cell proliferation by Tsc-22
Regulation of stem cell proliferation by Tsc-22
批准号:
20790220
负责人:
SUZUKI Hiroyuki
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
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英文摘要
Tsc-22 inhibits ES cell proliferation with maintaining the pluripotency. By analyzing the transcriptional factors that interact with Tsc-22 among Yamanaka factors (Oct4, c-Myc, Klf4 and Sox2), we found that Tsc-22 interacts c-Myc and Oct4. Tsc-22 suppresses the c-Myc/Oct4-mediated inhibition of p21 promoters. Furthermore, Tsc-22 interacts with ERas and inhibits PI3 kinase-Akt pathway.
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Differential regulation of c-Myc transcriptional activity by transforming growth factor-beta stimulated clone 22
转化生长因子-β刺激的克隆 22 对 c-Myc 转录活性的差异调节
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Hiroyuki Suzuki, Akinobu Nakano and Mitsuyasu Kato]
通讯作者:
Akinobu Nakano and Mitsuyasu Kato
Tsc-22 inhibits cellular proliferation through regulation of c-Myc and Oct4
Tsc-22 通过调节 c-Myc 和 Oct4 抑制细胞增殖
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Suzuki H, Nakajo Y, Nakano A, Nakayama. Y, Kato M]
通讯作者:
Kato M
TGF-β
转化生长因子-β
DOI:
--
发表时间:
2010
期刊:
間接リウマチ(日本臨床社) (印刷中)
影响因子:
--
作者:
[鈴木裕之, 青山知恵, 加藤光保]
通讯作者:
加藤光保
Regulation of cellular proliferation by transforming growth factor-β stimulated clone 22
通过转化生长因子-β 刺激的克隆 22 调节细胞增殖
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Suzuki H, Nakano A, Kato M]
通讯作者:
Kato M
DOI:
10.1016/j.bbrc.2008.08.143
发表时间:
2008-11
期刊:
Biochemical and biophysical research communications
影响因子:
3.1
作者:
[Bei Wang;Hiroyuki Suzuki;Mitsuyasu Kato]
通讯作者:
Bei Wang;Hiroyuki Suzuki;Mitsuyasu Kato
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