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Studies on Physiological Significance of Cytoskeleton Redistribution in the Mammalian Eggs and Its Signal Transduction Pathways

Studies on Physiological Significance of Cytoskeleton Redistribution in the Mammalian Eggs and Its Signal Transduction Pathways
哺乳动物卵细胞骨架重分配的生理意义及其信号转导途径研究
批准号:
21580340
负责人:
SUZUKI Hiroyuki
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
Function of cytoskeleton in the mammalian oocytes during maturation was examined. Results revealed that microfilaments and microtubules may be differently involved in the mitochondrial redistribution according to the interphase and M-phase of the cell cycle. Dynamics of the motor proteins, myosin and kinesin, during oocyte maturation was also clarified. Furthermore, the distributional changes of intermediate filament proteins keratin, vimentin and nestin were shown. Effects of the specific inhibitors of the cell-cycle regulating factors cdc2 and MAP kinase kinase or Rho kinase inhibition on the cytoskeletal architecture were evaluated.
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DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [古山敬一, 椛嶋克哉, 松崎正敏, 鈴木裕之, 椛嶋克哉・山内浩一・松崎正敏・鈴木裕之]
通讯作者: 椛嶋克哉・山内浩一・松崎正敏・鈴木裕之
ハムスター卵成熟過程におけるミトコンドリアの再配置は,微小管ではなくアクチン繊維によって制御される
仓鼠卵母细胞成熟过程中的线粒体重排是由肌动蛋白纤维而不是微管控制的
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Kabashima, K., Matsuzaki, M., Suzuki, H., 椛嶋克哉,房家.,松崎正敏,鈴木裕之]
通讯作者: 椛嶋克哉,房家.,松崎正敏,鈴木裕之
Intermediate filament keratin dynamics during oocyte maturation requires MPF and MAP kinase activities in the hamster
卵母细胞成熟过程中的中间丝角蛋白动力学需要仓鼠中的 MPF 和 MAP 激酶活性
DOI: --
发表时间: 2010
期刊: Reprod. Dom. Anim
影响因子: --
作者: [Kabashima, K., Matsuzaki, M. and Suzuki, H.]
通讯作者: H.
Intermediate Filament Keratin Dynamics During Oocyte Maturation Requires Maturation/M-Phase Promoting Factor and Mitogen-Activated Protein Kinase Kinase Activities in the Hamster
卵母细胞成熟过程中的中间丝状角蛋白动力学需要仓鼠中的成熟/M相促进因子和丝裂原激活蛋白激酶激酶活性
DOI: --
发表时间: 2010
期刊: Reproduction in Domestic Animals
影响因子: 1.7
作者: [Kabashima, K., Matsuzaki, M., Suzuki, H.]
通讯作者: H.
12
    Role of THG-1 in squamous cell carcinoma development and its application to cancer therapy
    Development of therapy for craniosynostosis in Apert syndrome by FGF signal control
    • 批准号:
      24890063
    • 项目类别:
      Grant-in-Aid for Research Activity Start-up
    • 资助金额:
      $1.91万
    • 财政年份:
      2012
    • 负责人:
      SUZUKI Hiroyuki
    • 依托单位:
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    • 批准号:
      24520103
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.33万
    • 财政年份:
      2012
    • 负责人:
      SUZUKI Hiroyuki
    • 依托单位:
    The present condition and the subject of a disaster prevention system that the large-scale disaster in a depopulated area was assumed
    • 批准号:
      23653126
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $1.25万
    • 财政年份:
      2011
    • 负责人:
      SUZUKI Hiroyuki
    • 依托单位:
    海外基金