Analysis of TCR regulation by a lysosomal protein LAPTM5

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Modulation of surface T cell antigen receptor (TCR) expression is an important mechanism for the regulation of immune responses and the prevention of T cell hyperactivation and autoimmunity. After antigen stimulation, TCR are internalized and degraded in lysosomes. However, few of the molecules involved in this process have been identified. We demonstrate that the lysosomal protein LAPTM5 negatively regulated surface TCR expression by promoting its degradation. These results identify a lysosomal protein illustrate a unique mechanism for the control of surface TCR expression and T cell activation.