The role of autoantigen presentation by autophagy of biliary epitherial cell in the pathogenesis of primary biliary cirrhosis.

分析胆汁上皮细胞自噬递呈自身抗原在原发性胆汁性肝硬化发病机制中的作用。LPS或CpGDNA刺激诱导BEC自噬，诱导BEC上MHCⅱ类抗原的表达。树突状细胞自噬诱导BEC后，体外免疫不诱导PDCE2特异性免疫耐受。在胆管损伤动物模型发生前给予自噬诱导BEC的树突状细胞，胆管损伤炎症较对照组略有改善。然而，当胆管损伤后给予树突状细胞自噬诱导的BEC时，没有观察到这种改善。

The role of autoantigen presentation by autophagy of biliary epitherial cell (BEC) in the pathogenesis of primary biliary cirrhosis was analyzed. Autophagy of BEC was induced by LPS or CpGDNA stimulation and the expression of MHC class II antigen on BEC was induced. PDCE2 specific immunological tolerance was not induced in vitro by immunization of dendritic cell which take autophagy induced BEC. When dendritic cell which take autophagy induced BEC was administered to the animal model of PBC before the bile duct damage was take place, inflammation with bile duct damage was slightly improved compared with control. However, such improvement was not observed when dendritic cell which take autophagy induced BEC was administered after the bile duct damage was take place.,