The relationship between Arteriosclerotic disease and Periodontal disease via endocannabinoid

在这项研究中，我们关注内源性大麻素（anandamide(AEA), 2-AG）作为估计动脉硬化疾病和牙周病之间关系的指标。探讨牙周进展与牙周袋AEA、2-AG及外周血总胆固醇、甘油三酯、AEA、2-AG的关系。牙周进展与上述所有因素均无显著关系。但随着牙周病的进展，尤其是心脏病患者，牙周病的发病率呈比例上升。这些结果表明，内源性大麻素在牙周袋内产生，这些大麻素通过血流影响全身代谢。

In this study, we focus on endocannainoid (anandamide(AEA), 2-AG) for an indicator of estimation of the relationship between Arteriosclerotic disease and Periodontal disease. We investigated the relationship between periodontal progression and AEA and 2-AG in periodontal pocket and total cholesterol, triglyceride, AEA and 2-AG inperipheral blood. None of significant relationship observed between periodontal progression and all of them.But they tend to increase proportionally with periodontal disease progression, especially in patient with heart disease. These results suggested that endocannabinoid are produced in periodontal pocket and these cannaibnoid affect systemic metabolism via blood flow.