The relationship between Arteriosclerotic disease and Periodontal disease via endocannabinoid

在这项研究中，我们专注于内cannainoid（anandamide（AEA），2-AG）的一个指标，估计动脉疾病和牙周病之间的关系。本研究探讨了牙周病进展与牙周袋中AEA、2-AG及外周血总胆固醇、甘油三酯、AEA、2-AG的关系。牙周病的进展与上述三项指标均无显著相关性，但随着牙周病的进展，尤其是心脏病患者，上述三项指标呈正比增加。这些结果表明，内源性大麻素产生于牙周袋，这些cannaiboid影响全身代谢通过血流。

In this study, we focus on endocannainoid (anandamide(AEA), 2-AG) for an indicator of estimation of the relationship between Arteriosclerotic disease and Periodontal disease. We investigated the relationship between periodontal progression and AEA and 2-AG in periodontal pocket and total cholesterol, triglyceride, AEA and 2-AG inperipheral blood. None of significant relationship observed between periodontal progression and all of them.But they tend to increase proportionally with periodontal disease progression, especially in patient with heart disease. These results suggested that endocannabinoid are produced in periodontal pocket and these cannaibnoid affect systemic metabolism via blood flow.