RAGE and soluble RAGE mediated regulation of obesity and atherosclerosis

晚期糖基化终末产物AGEs及其受体β 1参与了糖尿病血管并发症的发生。在本研究中，我们发现在非糖尿病状态下，脂联素参与高脂饮食诱导的肥胖和动脉粥样硬化，其中脂联素调节血浆脂联素起重要作用。此外，对RAGE缺陷脂肪组织特异性调节的mRNA的基因芯片分析表明，胰岛素信号传导和脂肪细胞分化途径是RAGE的潜在靶点，这可能有助于肥胖和改变脂肪细胞因子的调节。

Advanced glycation end-products, AGEs and their receptor, RAGE, has been implicated in vascular complications in diabetes. In this study, we show that RAGE is involved in adiposity and atherosclerosis induced by high fat diet in non-diabetic condition, where RAGE regulated plasma adiponectin take an important role. Moreover, gene chip analyses of mRNA specifically regulated by RAGE-deficient adipose tissues reveal that insulin signaling and adipocyte differentiation pathway are potential targets of RAGE, which could contribute to adiposity and altered adipocytokine regulation.