Obesity, atherosclerosis and RAGE-mediated inflammatory signal

晚期糖基化终产物受体（RAGE）深入参与慢性糖尿病血管并发症包括肾病和动脉粥样硬化的发病过程。在本研究项目中，我们通过体外脂肪生成模型系统和体内肥胖小鼠模型发现RAGE在肥胖、代谢综合征和胰岛素抵抗的病因学中发挥重要作用（Diabetes 2013）。在临床研究中，我们也在随机对照试验中直接与磺脲类药物进行比较，发现噻唑烷二酮类药物对RAGE系统有深远的影响（Atherosclerosis 2014）。

Receptor for advanced glycation end-products (RAGE) is deeply involved in pathogenesis of chronic diabetic vascular complications including nephropathy and atherosclerosis. In this research project, we have found that RAGE plays important roles in etiology of obesity, metabolic syndrome, and insulin resistance by using in vitro adipogenesis model system and in vivo obesity mouse model (Diabetes 2013). In clinical research, we have also found that thiazolidinediones have profound effects on RAGE system, by directly comparing with sulfonyurea in a randomized controlled trial (Atherosclerosis 2014).