Study for interaction between D-serine synthesis and development of morphine tolerance

D-丝氨酸合成与吗啡耐受性发展之间相互作用的研究

• 批准号: 20591843
• 负责人: ITO Kenji
• 金额: $ 3.08万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591843/
• 关键词: 疼痛管理学; モルヒネ; 麻薬; ケタミン; Dセリン; セリンラセマーゼ; Dアミノ酸酸化酵素; 鎮痛; 耐性; in situ hybridization; 免疫組織化学; NMDA受容体

Repeated administration of morphine for 30 days produced a significant augmentations of both the mRNA and protein expressions of serine racemase in all the brain regions, and caused a slight but significant elevation in the elevated D-seirne revel in the cortex, striatum and hippocampus. The antinociception induced by the intracerebroventricular (i.c.v.) administration of D-serine was attenuated by i.c.v. administration of midazolam. These results indicate the elevated D-serine level following the chronic morphine treatment could at least in part be involved in the activation of NMDA receptors via the glycine site.

吗啡重复给药30天后，各脑区丝氨酸消旋酶的mRNA和蛋白表达均显著增强，皮质、纹状体和海马区D-seirne的表达略有升高，但差异不显著。侧脑室(i.c.v.)静脉注射D-丝氨酸可减弱D-丝氨酸的作用。咪达唑仑的管理。这些结果表明，慢性吗啡治疗后D-丝氨酸水平的升高至少部分参与了NMDA受体通过甘氨酸部位的激活。

项目成果

Inhibitory effect of low-dose pentazocine on the development of antinociceptive tolerance to morphine

• DOI: 10.1007/s00540-008-0697-0
• 发表时间: 2009-02-01
• 期刊: JOURNAL OF ANESTHESIA
• 影响因子: 2.8
• 作者: Chiba, Shunsuke;Hayashida, Masakazu;Yamada, Yoshitsugu
• 通讯作者: Yamada, Yoshitsugu

Long-Torm Treatmont With Morphino Increases tho D-Seine Content in the Rat Brain by Regulating the mRNA and Protein Expressions of Serine Racemase and D-Amino Acid Oxidase

吗啡长效治疗通过调节丝氨酸消旋酶和 D-氨基酸氧化酶的 mRNA 和蛋白质表达来增加大鼠大脑中的 D-丝氨酸含量

• 发表时间: 2008
• 期刊: Journal of Pharmacological Sciences 107
• 作者: 樫葉均;仙波恵美子;Masanobu Yoshikawa
• 通讯作者: Masanobu Yoshikawa

Great increase in antinociceptive potency of [Leu5]enkephalin after peptidase inhibition

• DOI: 10.1254/jphs.fp0071318
• 发表时间: 2008-02-01
• 期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES
• 影响因子: 3.5
• 作者: Akahori, Kazuhito;Kosaka, Kenya;Oka, Tetsuo
• 通讯作者: Oka, Tetsuo

The Antinociceptive Effects of Midazolam on Three Different Types of Nociception in Mice

• DOI: 10.1254/jphs.08094fp
• 发表时间: 2009-01-01
• 期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES
• 影响因子: 3.5
• 作者: Chiba, Shunsuke;Nishiyama, Tomoki;Yamada, Yoshitsugu
• 通讯作者: Yamada, Yoshitsugu

ケタミン長期投与によるD-セリン代謝関連酵素遺伝子発現の変化

长期服用氯胺酮导致D-丝氨酸代谢相关酶基因表达的变化

• 发表时间: 2009
• 作者: 渡邊真理子;吉川正信;竹山和秀;村田智彦;金幸禄;小林智美;橋本篤司;小林広幸;鈴木利保
• 通讯作者: 鈴木利保