Development of New Treatment Strategies for Chronic Rhinosinusitis Based on Epigenetic Analysis

通过对难治性慢性鼻窦炎临床背景的调查，我们认为鼻窦黏膜对病毒感染的反应性存在差异。我们验证了ifn诱导的IP-10和I-TAC等基因是否表达，并比较了DNA甲基转移酶（DNMT）抑制剂和组蛋白去乙酰化酶（HDAC）抑制剂孵育前后的差异。我们发现组蛋白乙酰化参与转录调控。我们的目标是发现药物的表观遗传控制作为有效的治疗顽固性慢性鼻窦炎在未来。

As a results of investigation of clinical background concerning intractable chronic rhinosinusitis, we thought that nasal sinus mucosa differences in reactivity against virus infection exists. We verified whether or not the expression of IFN-induced genes such as IP-10 and I-TAC, compares the before and after the incubation with DNA methyltransferase (DNMT) inhibitors and histone deacetylase (HDAC) inhibitors. We identified that histone acetylation is involved in transcriptional regulation. We targeted to drug discovery for epigenetic control as effective therapy for intractable chronic rhinosinusitis in the future.