Development research into molecular diagnosis and treatment method of carcinoma of the oral cavity targeting WNT signal system transfer factor group

靶向WNT信号系统转移因子群的口腔癌分子诊疗方法开发研究

• 批准号: 20592360
• 负责人: KOIZUMI Koichi
• 金额: $ 3万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592360/
• 关键词: WNT; β-カテニン; 口腔癌; 診断; 治療法; Wntシグナル伝達経路

Oncogene β-katenin that was one of the Wnt signal system transfer factors had both the one to show the irregular accumulation to the cytoplasm and the nucleus in the culture oral carcinoma cell and the one not so. Moreover, the one in the part phosphorylated by GSK3 of β-katenin with the gene mutation and the one that not was existed in the cell that had abnormally accumulated β-katenin in the cytoplasm and the nucleus. Abnormal accumulation of β-katenin and the correlativity of the condition and the prognosis are being examined now.

是Wnt信号系统之一的癌基因β-katenin既可以表明培养口腔癌细胞中细胞质的不规则积累和细胞核的癌细胞，又显示了核。此外，β-katenin的GSK3磷酸化的部分中，基因突变和存在于细胞中绝对积累的β-katenin在细胞质和细胞核中的细胞中。现在正在检查β-katenin的异常积累以及病情和预后的相关性。

项目成果

β-catenin-independent Wnt signaling regulates cell migration, polarity and morphogenesis.

不依赖 β-连环蛋白的 Wnt 信号传导可调节细胞迁移、极性和形态发生。

• 发表时间: 2009
• 期刊: Tissue Culture Research Communications 28
• 作者: Matsumoto;S.;Okamoto;T.;Kikuchi;A.
• 通讯作者: A.

Growth factor-defined culture medium for human mesenchymal stem cells

• DOI: 10.1387/ijdb.103232sm
• 发表时间: 2011-01-01
• 期刊: INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
• 影响因子: 0.7
• 作者: Mimura, Sumiyo;Kimura, Naohiro;Furue, Miho K.
• 通讯作者: Furue, Miho K.

Advantages and difficulties in culturing human pluripotent stem cells in growth factor-defined serum-free medium.

• DOI: 10.1007/s11626-010-9317-z
• 发表时间: 2010-07
• 期刊: IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
• 影响因子: 2.1
• 作者: Furue, Miho Kusuda;Tateyama, Daiki;Kinehara, Masaki;Na, Jie;Okamoto, Tetsuji;Sato, J. Denry
• 通讯作者: Sato, J. Denry

Serum-free growth factor-defined cell culture of mouse ES cell.

小鼠 ES 细胞的无血清生长因子定义的细胞培养物。

• 发表时间: 2008
• 期刊: Tissue Culture Research Communications 27
• 作者: Hayashi;Y.;Kusuda;M.;Myoishi;Y.;Okamoto;T.
• 通讯作者: T.