Development research into molecular diagnosis and treatment method of carcinoma of the oral cavity targeting WNT signal system transfer factor group

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Oncogene β-katenin that was one of the Wnt signal system transfer factors had both the one to show the irregular accumulation to the cytoplasm and the nucleus in the culture oral carcinoma cell and the one not so. Moreover, the one in the part phosphorylated by GSK3 of β-katenin with the gene mutation and the one that not was existed in the cell that had abnormally accumulated β-katenin in the cytoplasm and the nucleus. Abnormal accumulation of β-katenin and the correlativity of the condition and the prognosis are being examined now.