Bovine lactoferrin-based agents which promotes healing of tooth socket

本研究评价乳铁蛋白对牙槽愈合的影响。取4周龄Wistar雄性大鼠，在全身麻醉下取出右下第一磨牙。将含有控释牛乳铁蛋白的胶原蛋白海绵置入牙槽内。一周后，这些老鼠被处死。采用三维图像和组织学图像评价牙槽的愈合情况。研究结果表明，控释牛乳铁蛋白可减少牙龈上皮下的中性粒细胞数量，增加新骨的形成。

Effects of lactoferrin on healing of tooth socket were evaluated in this investigation. Right lower first molar of 4 weeks-old Wistar male rats was extracted under general anesthesia. Collagen sponge containing controlled-released bovine lactoferrin was inserted in the tooth socket. One week later, the rats were sacrificed. Healing of tooth socket was evaluated with 3-D images and histological images. Results of the investigation showed that controlled-released bovine lactoferrin decreases the number of neutrophils under the gingival epithelium and increase new bone formation.