Bovine lactoferrin-based agents which promotes healing of tooth socket

促进牙槽愈合的牛乳铁蛋白制剂

• 批准号: 20592433
• 负责人: NAKASHIMA Keisuke
• 金额: $ 2.91万
• 依托单位: Kyushu Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592433/
• 关键词: 外科; 歯学; 生体分子; タンパク質; 動物; 蛋白質

Effects of lactoferrin on healing of tooth socket were evaluated in this investigation. Right lower first molar of 4 weeks-old Wistar male rats was extracted under general anesthesia. Collagen sponge containing controlled-released bovine lactoferrin was inserted in the tooth socket. One week later, the rats were sacrificed. Healing of tooth socket was evaluated with 3-D images and histological images. Results of the investigation showed that controlled-released bovine lactoferrin decreases the number of neutrophils under the gingival epithelium and increase new bone formation.

本研究旨在探讨乳铁蛋白对牙槽窝愈合的影响。取4周龄Wistar雄性大鼠右下第一磨牙，在全身麻醉下拔除。将含有控释牛乳铁蛋白的胶原蛋白海绵植入牙窝。一周后，大鼠被处死。用三维图像和组织学图像评价牙槽窝愈合情况。研究结果表明，控释的牛乳铁蛋白减少了牙龈上皮下中性粒细胞的数量，增加了新骨的形成。

项目成果

Effect of lactoferrin-embedded collagen membrane on osteogenic differentiation of human osteoblast-like cells.

• DOI: 10.1016/j.jbiosc.2008.09.018
• 发表时间: 2009-02
• 期刊: Journal of bioscience and bioengineering
• 影响因子: 2.8
• 作者: Y. Takayama;K. Mizumachi

Involvement of adhesion molecule in in vitro plaque-like formation of macrophages stimulated with Aggregatibacter actinomycetemcomitans lipopolysaccharide

• DOI: 10.1111/j.1600-0765.2010.01270.x
• 发表时间: 2010-08-01
• 期刊: JOURNAL OF PERIODONTAL RESEARCH
• 影响因子: 3.5
• 作者: Takeshi, T.;Keisuke, N.;Tatsuji, N.
• 通讯作者: Tatsuji, N.

The G1 cell cycle arrest of macrophages infected with Aggregatibacter actinomycetemcomitans

伴放线菌感染的巨噬细胞G1细胞周期停滞

• 发表时间: 2010
• 期刊: Oral Diseases 16
• 作者: Kasai H;中島啓介;Yokota M;Nishihara T
• 通讯作者: Nishihara T

ヒトラクトフェリンによるエンドトキシン作用の抑制

人乳铁蛋白抑制内毒素作用

• 发表时间: 2008
• 期刊: 歯界展望 112
• 作者: 中島啓介;湯本泰弘;古市保志
• 通讯作者: 古市保志

Nicotine induces upregulated expression of beta defensin-2 via the p38MAPK pathway in the HaCaT human keratinocyte cell line

• DOI: 10.1007/s00795-010-0493-4
• 发表时间: 2010-12-01
• 期刊: MEDICAL MOLECULAR MORPHOLOGY
• 影响因子: 1.8
• 作者: Nakamura, Sumiko;Saitoh, Masato;Abiko, Yoshihiro
• 通讯作者: Abiko, Yoshihiro