Research on defense of neurodegenerative disease by nutritional content

通过营养成分防御神经退行性疾病的研究

• 批准号: 20700614
• 负责人: TADA Osamu
• 金额: $ 2.08万
• 依托单位: Kagoshima Prefectural College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20700614/
• 关键词: 栄養学; 食品; 蛋白質; 脳神経疾患; 老化

Previously, it is known that the neuronal cell of the hippocampus drops out selectively by whole brain ischemia for a short time. It is clear that triggered by the activation of the intracellular protease such as calpain, cathepsins B, and L in this neuronal cell death. In the present study, the protective activity in the neuronal cell death at in vivo by the protein and the amino acid nutrition was examined by rat's ischemia. As a result, cysteine intake was demonstrated to inhibit the activation of the intracellular proteases, but even the maintenance of the nerve tissue at the histological analysis and the maintenance of the memory and the learning ability were not able to find the effect.

以前，已知海马的神经元细胞通过短时间的全脑缺血而选择性地脱落。很明显，由细胞内蛋白酶如钙蛋白酶、组织蛋白酶B和L的激活触发的这种神经元细胞死亡。在本研究中，蛋白质和氨基酸营养在体内的神经元细胞死亡的保护活性，通过大鼠的缺血检查。结果，半胱氨酸摄入被证明抑制细胞内蛋白酶的活化，但即使在组织学分析中维持神经组织以及维持记忆和学习能力也不能发现效果。