Identification of ubiquitin-dependent endosomal sorting signal in cytokine receptors

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In immune or nerve system, intracellular compartments maintain the function, which is supported by endosomal sorting, keeps the specific substances of the system and exchanges the substances between the compartments without physiological and morphological disorder. Here, we showed ubiquitin-independent endosomal sorting of interleukin-2 receptorβ(IL-2Rβ) and identified a novel endosomal sorting signal in the cytoplasmic region of IL-2Rβ. Our report provides the first description of endosomal sorting signal in a ubiquitin-independent manner.