Endosomal sorting signal of cytokine receptors and its single nucleotide polymorphism in allergy disease

过敏性疾病中细胞因子受体内体分选信号及其单核苷酸多态性

• 批准号: 25461586
• 负责人: TAKESHITA Toshikazu
• 金额: $ 3.16万
• 依托单位: Shinshu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25461586/
• 关键词: サイトカイン; サイトカイン受容体; アレルギー; 受容体遺伝子多型; 小胞輸送シグナル

项目成果

Hydrophobic amino acid cluster in the cytoplasmic tail of interleukin-2 receptor βchain acts as a sorting signal for lysosome

白细胞介素2受体β链胞质尾部的疏水性氨基酸簇充当溶酶体的分选信号

• 作者: 天野勇治;その他
• 通讯作者: その他

ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation

ESCRT-0蛋白肝细胞生长因子调节的酪氨酸激酶底物（Hrs）独立于信号转导接头分子（STAM）靶向内体，并且与STAM形成复合物促进其内体解离

• DOI: 10.1074/jbc.m114.578245
• 发表时间: 2014
• 期刊: J Biol Chem
• 影响因子: 4.8
• 作者: Kojima;K.;Amano;Y.;Yoshino;K.;Tanaka;N.;Sugamura;K.;Takeshita;T.
• 通讯作者: T.

A hydrophobic amino acid cluster inserted into the C-terminus of a recycling cell surface receptor functions as an endosomal sorting signal

• DOI: 10.1016/j.bbrc.2013.10.019
• 发表时间: 2013-11-08
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Amano, Yuji;Yoshino, Kazuhisa;Takeshita, Toshikazu
• 通讯作者: Takeshita, Toshikazu