Evaluation of endogenous retroviral genes at human cholestatic liver diseases

内源性逆转录病毒基因在人类胆汁淤积性肝病中的评价

• 批准号: 21590822
• 负责人: UENO Yoshiyuki
• 金额: $ 3万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590822/
• 关键词: 肝臓学; 原発性胆汁性肝硬変; 次世代シーケンサー; レトロウイルス; プロファイリング; 胆管上皮細胞; 胆汁うっ滞; モデルマウス; ORF

The pathogenesis of human cholestatic liver diseases remains to be unknown. Recently, the involvement of endogenous retroviral genes is reported in various human autoimmune diseases. In this study, we evaluated these genes in human samples as well as animal model. We detected some retroviral derived genes in female mouse liver. Furthermore, we have done several conditioning experiments using sensitive deep sequencing analyzer.

人类胆汁淤积性肝病的发病机制尚不清楚。近年来，内源性逆转录病毒基因参与了多种人类自身免疫性疾病的研究。在这项研究中，我们在人类样本和动物模型中评估了这些基因。我们在雌性小鼠的肝脏中检测到一些逆转录病毒来源的基因。此外，我们还利用灵敏的深度测序仪进行了多次条件性实验。

项目成果

H1 and H2 Histamine Receptor Agonists Differentially Stimulate the Regeneration of Small and Large Cholangiocytes by Activation of Ca (2+) and Camp-Dependent Mechanisms, Respectively

H1 和 H2 组胺受体激动剂分别通过激活 Ca (2 ) 和 Camp 依赖性机制差异刺激小胆管细胞和大胆管细胞的再生

• 发表时间: 2011
• 作者: Francis HL;Meng F;Onori P;Venter J;White M;Ueno Y;Franchitto A;Renzi A;Gaudio E;Alpini G
• 通讯作者: Alpini G

Adenosine Triphosphate Release and Purinergic (P2) Receptor-Mediated Secretion in Small and Large Mouse Cholangiocytes

• DOI: 10.1002/hep.23883
• 发表时间: 2010-11-01
• 期刊: HEPATOLOGY
• 影响因子: 13.5
• 作者: Woo, Kangmee;Sathe, Meghana;Feranchak, Andrew P.
• 通讯作者: Feranchak, Andrew P.

Knockout of secretin receptor reduces large cholangiocyte hyperplasia in mice with extrahepatic cholestasis induced by bile duct ligation.

• DOI: 10.1002/hep.23657
• 发表时间: 2010-07
• 期刊: HEPATOLOGY
• 影响因子: 13.5
• 作者: Glaser, Shannon;Lam, Ian P.;Franchitto, Antonio;Gaudio, Eugenio;Onori, Paolo;Chow, Billy K.;Wise, Candace;Kopriva, Shelley;Venter, Julie;White, Mellanie;Ueno, Yoshiyuki;Dostal, David;Carpino, Guido;Mancinelli, Romina;Butler, Wendy;Chiasson, Valorie;DeMorrow, Sharon;Francis, Heather;Alpini, Gianfranco
• 通讯作者: Alpini, Gianfranco

H1 and H2 Histamine Receptor Agonists Differentially Stimulate the Regeneration of Small and Large Cholangiocytes by Activation of Ca(2+)and Camp-Dependent Mechanisms, Respectively

H1 和 H2 组胺受体激动剂分别通过激活 Ca(2) 和 Camp 依赖性机制差异刺激小胆管细胞和大胆管细胞的再生

• 发表时间: 2011
• 作者: Francis HL;Meng F;Onori P;Venter J;White M;Ueno Y;Franchitto A;Renzi A;Gaudio E;Alpini G
• 通讯作者: Alpini G

Compensatory role of inducible annexin A2 for impaired biliary epithelial anion-exchange activity of inflammatory cholangiopathy.

诱导型膜联蛋白 A2 对炎症性胆管病胆管上皮阴离子交换活性受损的代偿作用。

• DOI: 10.1038/labinvest.2009.105
• 发表时间: 2009
• 期刊: Laboratory investigation; a journal of technical methods and pathology
• 作者: Kido,Osamu;Fukushima,Koji;Ueno,Yoshiyuki;Inoue,Jun;Jefferson,DouglasM;Shimosegawa,Tooru
• 通讯作者: Shimosegawa,Tooru