Modification of Cardiovascular Remodeling via Heat Shock Protein and Repair of Oxidative DNA damage

DNA损伤是动脉粥样硬化性心血管疾病的主要原因之一。我们重点研究了碱基切除修复系统中的主要酶--APEP1。APE-1基因在受损的心血管病变中高表达，并且APE-1基因的转染有效地阻止了心血管重构。41摄氏度的热处理诱导热休克蛋白(HSP)72的表达，并降低氧化应激。APE1和HSP72同时显示出抗动脉粥样硬化的作用，是一种潜在的抑制心血管重构的新策略。

DNA damage is one of the major cause of atherosclerotic cardiovascular diseases. We focused on Ape 1, themajor enzyme of base excision repair system. Ape 1 was highly expressed in a damaged cardiovascular lesion, and the transfection of Ape 1 gene effectively prevented cardiovascular remodeling. Thermal treatment at 41 degree Celsius induced heat shock protein (HSP) 72 expression, and reduced oxidative stress. Ape1 and HSP 72 additively show an antiatherosclerotic action and are a potential new strategy for suppression of cardiovascular remodeling.