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Role of AT2 Receptor on Insulin Resistance and Adipose Tissue Dysfunction in Atherosclerotic Mouse Model

Role of AT2 Receptor on Insulin Resistance and Adipose Tissue Dysfunction in Atherosclerotic Mouse Model
AT2 受体对动脉粥样硬化小鼠模型胰岛素抵抗和脂肪组织功能障碍的作用
批准号:
21590956
负责人:
IWAI Masaru
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
In the comparison with ApoEKO mice, AT2 deficient(AT2/ApoE knockout) mice showed the increase in adipose tissue weight, adipocyte size, markers for adipocyte differentiation and insulin resistance. AT2/ApoEKO mice also showed the decrease in cholesterol excretion into bile and feces. These results suggest that AT2 receptor stimulation induces improvement of adipocyte function and cholesterol metabolism and that these effects may be useful for the therapy for metabolic syndrome in the near future.
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DOI: 10.1016/j.jash.2011.01.007
发表时间: 2011-03
期刊: Journal of the American Society of Hypertension : JASH
影响因子: --
作者: [Midori Okumura;M. Iwai;Hirotomo Nakaoka;H. Sone;H. Kanno;Izumi Senba;Masaharu Ito;M. Horiuchi]
通讯作者: Midori Okumura;M. Iwai;Hirotomo Nakaoka;H. Sone;H. Kanno;Izumi Senba;Masaharu Ito;M. Horiuchi
Deletion of the Angiotensin II Type 1a Receptor Prevents Athero sclerotic Plaque Rupture
血管紧张素 II 1a 型受体的缺失可预防动脉粥样硬化斑块破裂
DOI: --
发表时间: 2012
期刊: Arterioscle Thromb Vasc Biol
影响因子: --
作者: [Jun Aono, Jun Suzuki, et al]
通讯作者: et al
DOI: 10.1016/j.bbrc.2011.02.007
发表时间: 2011-03-04
期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子: 3.1
作者: [Iwai, Masaru, Kanno, Harumi, Horiuchi, Masatsugu]
通讯作者: Horiuchi, Masatsugu
Improvement of glucose intolerance by combination of pravastatin and olmesartan in type 2 diabetic KK-Ay mice
普伐他汀联合奥美沙坦改善 2 型糖尿病 KK-Ay 小鼠的葡萄糖耐受不良
DOI: --
发表时间: 2009
期刊: Hypertens Res
影响因子: 5.4
作者: [Kanno H, Iwai M, Inaba S, Senba I, Tomono Y, Mogi M, Horiuchi M]
通讯作者: Horiuchi M
27
    Important Role of Angiotensin Receptor Subtype in Adipocyte Differentiation and Insulin Resistance
    • 批准号:
      18590992
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.48万
    • 财政年份:
      2006
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    • 批准号:
      14570669
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
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    • 财政年份:
      2002
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      12670496
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $0.38万
    • 财政年份:
      2000
    • 负责人:
      IWAI Masaru
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    • 批准号:
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    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.41万
    • 财政年份:
      1996
    • 负责人:
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