Investigation of the inhibitory factors for osseointegration in the early stage of the implantation.

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We comprehensively evaluated by whole genome microarray analysis for the variation of gene organization around titanium implants were implanted in the femur in rats, and we compared gene expression in a rat model of acquired and non-acquired osseointegration. This study suggested that the expression of genes may be involved in bone formation in the establishment of osseointegration, but that the various genes expressed in a complex were assosiated with failure of osseointegration.